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Title: Chromosome aberrations as a biological dosimeter in Thorotrast patients: dosimetric problems

Abstract

The results of chromosome aberration analyses in 68 Thorotrast patients are discussed. In all patients dicentric chromosome aberrations were found but the chromosome aberration rate neither corresponds with the calculated whole body activity or the estimated absorbed dose in the organs of the RHS nor with the radium-224-equivalent value calculated from the radon-220 activity measured in the expired air. From x-ray examinations and histologic studies of lymph nodes the conclusion is drawn that the microdose absorbed from one lymphocyte is not in relation to the mean absorbed RHS dose, calculated from biophysical measurements.

Authors:
; ;
Publication Date:
Research Org.:
Universitaet des Saarlandes, Homburg, Germany
OSTI Identifier:
5511272
Resource Type:
Journal Article
Journal Name:
Environ. Res.; (United States)
Additional Journal Information:
Journal Volume: 18:1
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; CHROMOSOMAL ABERRATIONS; RADIOINDUCTION; DICENTRIC CHROMOSOMES; BIOLOGICAL RADIATION EFFECTS; LYMPH NODES; RETICULOENDOTHELIAL SYSTEM; THOROTRAST; DOSE-RESPONSE RELATIONSHIPS; HISTOLOGY; PATIENTS; RADIATION DOSES; RADIONUCLIDE KINETICS; ACTINIDE COMPOUNDS; BIOLOGICAL EFFECTS; BODY; CHALCOGENIDES; CHROMOSOMES; COLLOIDS; CONTRAST MEDIA; DISPERSIONS; DOSES; LYMPHATIC SYSTEM; MUTATIONS; OXIDES; OXYGEN COMPOUNDS; RADIATION EFFECTS; RADIOCOLLOIDS; THORIUM COMPOUNDS; THORIUM OXIDES; TISSUES; 560171* - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987); 550601 - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Kemmer, W., Steinstraesser, A., and Muth, H. Chromosome aberrations as a biological dosimeter in Thorotrast patients: dosimetric problems. United States: N. p., 1979. Web. doi:10.1016/0013-9351(79)90151-8.
Kemmer, W., Steinstraesser, A., & Muth, H. Chromosome aberrations as a biological dosimeter in Thorotrast patients: dosimetric problems. United States. doi:10.1016/0013-9351(79)90151-8.
Kemmer, W., Steinstraesser, A., and Muth, H. Thu . "Chromosome aberrations as a biological dosimeter in Thorotrast patients: dosimetric problems". United States. doi:10.1016/0013-9351(79)90151-8.
@article{osti_5511272,
title = {Chromosome aberrations as a biological dosimeter in Thorotrast patients: dosimetric problems},
author = {Kemmer, W. and Steinstraesser, A. and Muth, H.},
abstractNote = {The results of chromosome aberration analyses in 68 Thorotrast patients are discussed. In all patients dicentric chromosome aberrations were found but the chromosome aberration rate neither corresponds with the calculated whole body activity or the estimated absorbed dose in the organs of the RHS nor with the radium-224-equivalent value calculated from the radon-220 activity measured in the expired air. From x-ray examinations and histologic studies of lymph nodes the conclusion is drawn that the microdose absorbed from one lymphocyte is not in relation to the mean absorbed RHS dose, calculated from biophysical measurements.},
doi = {10.1016/0013-9351(79)90151-8},
journal = {Environ. Res.; (United States)},
number = ,
volume = 18:1,
place = {United States},
year = {1979},
month = {2}
}