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Title: Carcinogenesis by Thorotrast and other sources of irradiation, especially other. cap alpha. -emitters

Abstract

Carcinogenesis by ..cap alpha..-particles has special features due to inhomogeneous tissue irradiation causing focal tissue damage. Focal damage implies a linear relationship between carcinogenesis and dose, but due to the length of an ..cap alpha..-track in tissue exceeding cell size linearity doses not necessarily imply malignant transformations as exclusively intracellular processes. Thorotrast is an unsatisfactory model for other ..cap alpha..-emitters since in most Thorotrast patients the liver is structurally abnormal as a consequence of tissue damage. Better understanding of the observations on Thorotrast patients require subdivision of patients according to the volume of Thorotrast administered for better defined dose response relationships and experiments to show whether chemical toxicity as well as ..cap alpha..-radioactivity contributes to tissue damage. (DP)

Authors:
Publication Date:
Research Org.:
MRC Radiobiology Unit, Harwell, England
OSTI Identifier:
5511258
Resource Type:
Journal Article
Journal Name:
Environ. Res.; (United States)
Additional Journal Information:
Journal Volume: 18:1
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; ALPHA DECAY RADIOISOTOPES; DOSE-RESPONSE RELATIONSHIPS; BONE TISSUES; BIOLOGICAL RADIATION EFFECTS; CARCINOGENESIS; RADIOINDUCTION; LIVER; LUNGS; THOROTRAST; BIOLOGICAL MODELS; EXPERIMENTAL DATA; ISOLATED VALUES; LET; RBE; ACTINIDE COMPOUNDS; BIOLOGICAL EFFECTS; BODY; CHALCOGENIDES; COLLOIDS; CONNECTIVE TISSUE; CONTRAST MEDIA; DATA; DATA FORMS; DIGESTIVE SYSTEM; DISPERSIONS; ENERGY TRANSFER; GLANDS; INFORMATION; ISOTOPES; NUMERICAL DATA; ORGANS; OXIDES; OXYGEN COMPOUNDS; PATHOGENESIS; RADIATION EFFECTS; RADIOCOLLOIDS; RADIOISOTOPES; RESPIRATORY SYSTEM; THORIUM COMPOUNDS; THORIUM OXIDES; TISSUES; 560171* - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987); 560161 - Radionuclide Effects, Kinetics, & Toxicology- Man; 550601 - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Mole, R.H. Carcinogenesis by Thorotrast and other sources of irradiation, especially other. cap alpha. -emitters. United States: N. p., 1979. Web.
Mole, R.H. Carcinogenesis by Thorotrast and other sources of irradiation, especially other. cap alpha. -emitters. United States.
Mole, R.H. Thu . "Carcinogenesis by Thorotrast and other sources of irradiation, especially other. cap alpha. -emitters". United States.
@article{osti_5511258,
title = {Carcinogenesis by Thorotrast and other sources of irradiation, especially other. cap alpha. -emitters},
author = {Mole, R.H.},
abstractNote = {Carcinogenesis by ..cap alpha..-particles has special features due to inhomogeneous tissue irradiation causing focal tissue damage. Focal damage implies a linear relationship between carcinogenesis and dose, but due to the length of an ..cap alpha..-track in tissue exceeding cell size linearity doses not necessarily imply malignant transformations as exclusively intracellular processes. Thorotrast is an unsatisfactory model for other ..cap alpha..-emitters since in most Thorotrast patients the liver is structurally abnormal as a consequence of tissue damage. Better understanding of the observations on Thorotrast patients require subdivision of patients according to the volume of Thorotrast administered for better defined dose response relationships and experiments to show whether chemical toxicity as well as ..cap alpha..-radioactivity contributes to tissue damage. (DP)},
doi = {},
journal = {Environ. Res.; (United States)},
number = ,
volume = 18:1,
place = {United States},
year = {1979},
month = {2}
}