Immunologic and hematopoietic alterations by 2,450-MHz electromagnetic radiation
A biphasic modulation of responsiveness of spleen lymphocytes to mitogens was observed in mice exposed to 2,450-MHz radiation at power densities of 5-15 mW/cm2 over various periods ranging between one and 17 days. This modulated phenomenon may be explained on the basis of 1) suppression of lymphocyte response to microwave-activated macrophages which persists throughout the entire course of radiation, and 2) concurrent progressive direct stimulation of lymphocytes which culminates around day 9 of exposure. Tumor cytotoxicity of killer lymphocytes from mice exposed to five or nine days of radiation did not appear different from sham controls. The highly proliferative hematopoietic marrow cells were sensitive to microwave radiation. Nine days of exposure to radiation (15 mW/cm2) reduced the colony-forming units of myeloid and erythroid series by 50%. This observation may offer a new and more sensitive assay for studying biological effects of electromagnetic radiation.
- OSTI ID:
- 5509449
- Journal Information:
- Bioelectromagnetics (N.Y.); (United States), Vol. 1:1
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
BONE MARROW CELLS
SENSITIVITY
LYMPHOCYTES
MICROWAVE RADIATION
BIOLOGICAL EFFECTS
CFU
FRACTIONATED IRRADIATION
IMMUNE REACTIONS
MACROPHAGES
MICE
MITOGENS
POWER DENSITY
SPLEEN
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
IRRADIATION
LEUKOCYTES
MAMMALS
MATERIALS
ORGANS
PHAGOCYTES
RADIATIONS
RODENTS
SOMATIC CELLS
VERTEBRATES
560400* - Other Environmental Pollutant Effects
550300 - Cytology