Mutagenic effect of radionuclides incorporated into DNA of Drosophila melanogaster. Technical progress report, December 15, 1985-July 15, 1986

Technical Report · Wed Jan 01 00:00:00 EST 1986

OSTI ID:5499690

Lee, W R

This project compares the mutagenic effect of ionizing radiation from tritium to that of x-ray. Mutants are described at the molecular level after having been characterized by classical genetic techniques in Drosophila melanogaster, therefore tying together the molecular studies with previous work in mutagenesis. The objectives of this project are to analyze x-ray and tritium induced mutants by ''walking down'' the chromosomes and studying the frequency of breaks that are not associated with the gene used in screening for the mutants, to study the molecular effect of these mutants in heterozygotes with the aim of developing methods of detecting mutants in heterozygotes that may be applicable to human populations, and to induce mutants from tritium beta radiation and analyze them at the molecular level. 9 refs., 4 figs.

• Research Organization: Louisiana State Univ., Baton Rouge (USA). Dept. of Zoology and Physiology
• DOE Contract Number: FG05-86ER60393
• OSTI ID: 5499690
• Report Number(s): DOE/ER/60393-1; ON: DE86014680
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
TRITIUM
MUTAGENESIS
X RADIATION
AUTORADIOGRAPHY
DROSOPHILA
ELECTROPHORESIS
MUTATION FREQUENCY
ANIMALS
ARTHROPODS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
DIPTERA
ELECTROMAGNETIC RADIATION
FLIES
FRUIT FLIES
HYDROGEN ISOTOPES
INSECTS
INVERTEBRATES
IONIZING RADIATIONS
ISOTOPES
LIGHT NUCLEI
NUCLEI
ODD-EVEN NUCLEI
RADIATIONS
RADIOISOTOPES
YEARS LIVING RADIOISOTOPES
560162* - Radionuclide Effects
Kinetics
& Toxicology- Animals
Plants
Microorganisms
& Cells
560153 - Radiation Effects on Animals- Invertebrates- (-1987)