Urine recovery experiments with quercetin and other mutagens using the Ames test
Journal Article
·
· Environ. Mutagen.; (United States)
Recovery from urine of the mutagenic activity of 2-anthramine, cyclophosphamide, 7,12-dimethylbenz(a)anthracene, 6-chloro-9-((3-(2-chloroethylamino)-propyl)amino)-2-methoxyacridine dihydrochloride (ICR-191), mitomycin-C, nitrofurantoin, and quercetin was studied with several of the Ames tester strains using acetone-extracted XAD-2 columns with yields ranging from 27% to 79%. Dose responses of the pure chemicals were also studied, and results showed TA 97 to be far more susceptible to quercetin mutagenesis than TA 1537. Reducing pour plate agar volume enhanced mutagenesis.
- Research Organization:
- Wisconsin Clinical Cancer Center, Madison
- OSTI ID:
- 5498928
- Journal Information:
- Environ. Mutagen.; (United States), Vol. 8:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
DIMETHYLBENZANTHRACENE
GENETIC EFFECTS
ENDOXAN
FURANS
MITOMYCIN
QUERCETIN
URINE
MUTAGEN SCREENING
DOSE-RESPONSE RELATIONSHIPS
NITRO COMPOUNDS
SALMONELLA TYPHIMURIUM
ALKYLATING AGENTS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
AROMATICS
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CONDENSED AROMATICS
DRUGS
FLAVENOIDS
FLAVONES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IMMUNOSUPPRESSIVE DRUGS
MATERIALS
MICROORGANISMS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PHENOLS
POLYPHENOLS
PYRANS
SALMONELLA
SCREENING
WASTES
560302* - Chemicals Metabolism & Toxicology- Microorganisms- (-1987)
DIMETHYLBENZANTHRACENE
GENETIC EFFECTS
ENDOXAN
FURANS
MITOMYCIN
QUERCETIN
URINE
MUTAGEN SCREENING
DOSE-RESPONSE RELATIONSHIPS
NITRO COMPOUNDS
SALMONELLA TYPHIMURIUM
ALKYLATING AGENTS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
AROMATICS
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CONDENSED AROMATICS
DRUGS
FLAVENOIDS
FLAVONES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IMMUNOSUPPRESSIVE DRUGS
MATERIALS
MICROORGANISMS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PHENOLS
POLYPHENOLS
PYRANS
SALMONELLA
SCREENING
WASTES
560302* - Chemicals Metabolism & Toxicology- Microorganisms- (-1987)