Anesthetic-resistant spontaneous mutant of Drosophila melanogaster: intensified response to /sup 60/Cobalt radiation damage

Journal Article · Mon Feb 25 00:00:00 EST 1985 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(85)90200-0· OSTI ID:5483604

Gamo, S; Nakashima-Tanaka, E; Megumi, T; Ueda, I

Accumulating evidence suggests that the extent of acute damage by ionizing irradiation is closely related to the state of membrane orderliness. Decreased orderliness apparently protects organisms from ionizing irradiation. Because anesthetics decrease membrane orderliness, anesthesia is expected to affect damages caused by ionizing irradiation. The present study compared the effects of /sup 60/Co irradiation on Drosophila melanogaster between an anesthetic-resistant spontaneous mutant and an anesthetic-sensitive strain. An anesthetic-resistant mutant strain, Eth-29, of Drosophila melanogaster has previously been established. Eth-29 is resistant to diethyl-ether, chloroform and halothane. The anesthetic-resistant strain was found to be radiosensitive when evaluated by survival at the eighth day after irradiation or by dyskinesia (knock-down) at the second day. The results indicate that anesthetic resistance may be related to an increase in orderliness. The findings in reciprocal crosses between Eth-29 and the control strain indicate that the mechanism of survival is different from that of knock-down. Presumably, knock-down is the direct sequela of irradiation, and the present result suggests that membrane damage may be involved in inducing knock-down. 18 references, 3 figures.

• Research Organization: Univ. of Osaka Prefecture, Japan
• OSTI ID: 5483604
• Journal Information: Life Sci.; (United States), Vol. 36:8
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANESTHETICS
BIOLOGICAL EFFECTS
DROSOPHILA
BIOLOGICAL RADIATION EFFECTS
RADIOSENSITIVITY
CELL MEMBRANES
COBALT 60
MUTANTS
SURVIVAL TIME
ANIMALS
ARTHROPODS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CELL CONSTITUENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
COBALT ISOTOPES
DIPTERA
DRUGS
FLIES
FRUIT FLIES
INSECTS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INVERTEBRATES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEMBRANES
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
RADIATION EFFECTS
RADIOISOTOPES
YEARS LIVING RADIOISOTOPES
560153* - Radiation Effects on Animals- Invertebrates- (-1987)