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Title: Biokinetics aand dosimetry of inhaled {sup 238}PuO{sub 2} in the beagle dog: An update

Abstract

The temporal and spatial distributions of {sup 238}Pu have been measured during the course of a dose-response study of the biological effects of inhaled {sup 238}PuO{sub 2} in Beagle dogs. These measurements were done on the dose-response study animals, as well as a separate group of dogs exposed to similar aerosols and killed serially out to 4 y after exposure. The data from this latter group provided the basis for the development of a biokinetic/dosimetric model for {sup 238}PuO{sub 2} in dogs. Since the publication of this model, several important findings have been made that affected the dosimetric evaluations. The first involved the discovery of significant quantities of natural uranium (U) in the feces samples. The U was measured with the plutonium (Pu), which inflated the values for purported Pu in feces. The second finding involved the addition of Pu biokinetics data from the dose-response dogs, which increased the period of observation from 4 y to 15 y; these later data were not consistent with the earlier model predictions. The purpose of this investigation was (1) to remove the analytical bias in the {sup 238}Pu radiochemical data due to the U and (2) to modify the original model of Mewhinneymore » and Diel, taking into account all data from both studies.« less

Authors:
; ;
Publication Date:
Research Org.:
Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States). Inhalation Toxicology Research Inst.
OSTI Identifier:
54831
Report Number(s):
ITRI-144
ON: DE95007526; TRN: 95:012773
DOE Contract Number:  
AC04-76EV01013
Resource Type:
Technical Report
Resource Relation:
Other Information: PBD: Nov 1994; Related Information: Is Part Of Inhalation Toxicology Research Institute annual report, October 1, 1993--September 30, 1994; Belinsky, S.A.; Hoover, M.D.; Bradley, P.L. [eds.]; PB: 211 p.
Country of Publication:
United States
Language:
English
Subject:
56 BIOLOGY AND MEDICINE, APPLIED STUDIES; BEAGLES; BIOLOGICAL EFFECTS; PLUTONIUM OXIDES; SPATIAL DISTRIBUTION; TIME DEPENDENCE; INHALATION; DOSE-RESPONSE RELATIONSHIPS; BIOLOGICAL MODELS; PROGRESS REPORT; DOSIMETRY; URANIUM; FECES

Citation Formats

Guilmette, R A, Griffith, W C, and Diel, J H. Biokinetics aand dosimetry of inhaled {sup 238}PuO{sub 2} in the beagle dog: An update. United States: N. p., 1994. Web.
Guilmette, R A, Griffith, W C, & Diel, J H. Biokinetics aand dosimetry of inhaled {sup 238}PuO{sub 2} in the beagle dog: An update. United States.
Guilmette, R A, Griffith, W C, and Diel, J H. 1994. "Biokinetics aand dosimetry of inhaled {sup 238}PuO{sub 2} in the beagle dog: An update". United States.
@article{osti_54831,
title = {Biokinetics aand dosimetry of inhaled {sup 238}PuO{sub 2} in the beagle dog: An update},
author = {Guilmette, R A and Griffith, W C and Diel, J H},
abstractNote = {The temporal and spatial distributions of {sup 238}Pu have been measured during the course of a dose-response study of the biological effects of inhaled {sup 238}PuO{sub 2} in Beagle dogs. These measurements were done on the dose-response study animals, as well as a separate group of dogs exposed to similar aerosols and killed serially out to 4 y after exposure. The data from this latter group provided the basis for the development of a biokinetic/dosimetric model for {sup 238}PuO{sub 2} in dogs. Since the publication of this model, several important findings have been made that affected the dosimetric evaluations. The first involved the discovery of significant quantities of natural uranium (U) in the feces samples. The U was measured with the plutonium (Pu), which inflated the values for purported Pu in feces. The second finding involved the addition of Pu biokinetics data from the dose-response dogs, which increased the period of observation from 4 y to 15 y; these later data were not consistent with the earlier model predictions. The purpose of this investigation was (1) to remove the analytical bias in the {sup 238}Pu radiochemical data due to the U and (2) to modify the original model of Mewhinney and Diel, taking into account all data from both studies.},
doi = {},
url = {https://www.osti.gov/biblio/54831}, journal = {},
number = ,
volume = ,
place = {United States},
year = {1994},
month = {11}
}

Technical Report:
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