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Title: In vivo mutagenicity and clastogenicity of ionizing radiation in nuclear medicine

Abstract

The overall goal of our research was to investigate the mutagenic and clastogenic effects of exposure to low levels of ionizing radiation to human lymphocytes. Principally, we studied hospital patients referred to a nuclear medicine department for diagnostic cardiac imaging and nuclear medicine technologists who administer radionuclides. Emphasis in the first year, as described in the first progress report, was on optimization of the hprt mutation assay, measurement of mutant frequencies in patients imaged with thallium-201, and measurement of mutant frequencies in controls. Emphasis in the second and third years was on measurements of: (1) chromosome aberrations in patients imaged with thallium-201; (2) mutant frequencies in patients imaged with technetium-99; (3) mutant frequencies in nuclear medicine technicians and physical therapists; and (4) mutant frequencies in patients treated for Hodgkins disease with radiotherapy. The completed work has been published and is described below in more detail.

Authors:
Publication Date:
Research Org.:
Harvard Univ., Boston, MA (United States). School of Public Health
Sponsoring Org.:
USDOE; USDOE, Washington, DC (United States)
OSTI Identifier:
5482450
Report Number(s):
DOE/ER/60745-4
ON: DE92011571
DOE Contract Number:  
FG02-89ER60745
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; HUMAN POPULATIONS; GENETIC RADIATION EFFECTS; CHROMOSOMAL ABERRATIONS; IN VIVO; IONIZING RADIATIONS; MUTAGENESIS; PROGRESS REPORT; TECHNETIUM 99; THALLIUM 201; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; DAYS LIVING RADIOISOTOPES; DOCUMENT TYPES; ELECTRON CAPTURE RADIOISOTOPES; GENETIC EFFECTS; HEAVY NUCLEI; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MUTATIONS; NUCLEI; ODD-EVEN NUCLEI; POPULATIONS; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; SECONDS LIVING RADIOISOTOPES; TECHNETIUM ISOTOPES; THALLIUM ISOTOPES; YEARS LIVING RADIOI; 560120* - Radiation Effects on Biochemicals, Cells, & Tissue Culture; 550400 - Genetics

Citation Formats

Kelsey, K T. In vivo mutagenicity and clastogenicity of ionizing radiation in nuclear medicine. United States: N. p., 1991. Web. doi:10.2172/5482450.
Kelsey, K T. In vivo mutagenicity and clastogenicity of ionizing radiation in nuclear medicine. United States. https://doi.org/10.2172/5482450
Kelsey, K T. 1991. "In vivo mutagenicity and clastogenicity of ionizing radiation in nuclear medicine". United States. https://doi.org/10.2172/5482450. https://www.osti.gov/servlets/purl/5482450.
@article{osti_5482450,
title = {In vivo mutagenicity and clastogenicity of ionizing radiation in nuclear medicine},
author = {Kelsey, K T},
abstractNote = {The overall goal of our research was to investigate the mutagenic and clastogenic effects of exposure to low levels of ionizing radiation to human lymphocytes. Principally, we studied hospital patients referred to a nuclear medicine department for diagnostic cardiac imaging and nuclear medicine technologists who administer radionuclides. Emphasis in the first year, as described in the first progress report, was on optimization of the hprt mutation assay, measurement of mutant frequencies in patients imaged with thallium-201, and measurement of mutant frequencies in controls. Emphasis in the second and third years was on measurements of: (1) chromosome aberrations in patients imaged with thallium-201; (2) mutant frequencies in patients imaged with technetium-99; (3) mutant frequencies in nuclear medicine technicians and physical therapists; and (4) mutant frequencies in patients treated for Hodgkins disease with radiotherapy. The completed work has been published and is described below in more detail.},
doi = {10.2172/5482450},
url = {https://www.osti.gov/biblio/5482450}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 01 00:00:00 EST 1991},
month = {Tue Jan 01 00:00:00 EST 1991}
}