Decreased expression of HLA class II antigens on human uveal melanoma cells after in vivo X-ray irradiation

Journal Article · Fri Jan 15 00:00:00 EST 1988 · Am. J. Ophthalmol.; (United States)

DOI:https://doi.org/10.1016/0002-9394(88)90125-0· OSTI ID:5479758

Jager, M J; van der Pol, J P; de Wolff-Rouendaal, D; de Jong, P T; Ruiter, D J

In order to determine the presence of HLA antigens on human uveal melanomas, we tested anti-HLA monoclonal antibodies on tissue sections of these tumors. A great variety in expression of HLA class I and II antigens was present. A significantly lower expression of HLA class II antigens was present on uveal melanomas that had been irradiated before enucleation. These tumors lacked a lymphocytic infiltrate in comparison with nonirradiated tumors. These data suggest that radiotherapy affects expression of histocompatibility antigens on tumors.

• Research Organization: Univ. of Amsterdam, The Netherlands
• OSTI ID: 5479758
• Journal Information: Am. J. Ophthalmol.; (United States), Vol. 105:1
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
MELANOMAS
RADIOIMMUNOTHERAPY
UVEA
ANTIGENS
MONOCLONAL ANTIBODIES
X RADIATION
ANTIBODIES
BODY
BODY AREAS
DISEASES
ELECTROMAGNETIC RADIATION
EYES
FACE
HEAD
IMMUNOLOGY
IONIZING RADIATIONS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
RADIATIONS
RADIOIMMUNOLOGY
RADIOLOGY
RADIOTHERAPY
SENSE ORGANS
THERAPY
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)