Enterohepatic circulation in man of a gamma-emitting bile-acid conjugate, 23-selena-25-homotaurocholic acid (SeHCAT)
A conjugated bile acid, 23-selena-25-homotaurocholic acid (SeHCAT), labeled with the gamma emitter Se-75, has been evaluated in man. Absorption and excretion were compared with that of simultaneously administered (23-14C)cholic acid. SeHCAT is absorbed quantitatively following oral administration, secreted into the bile at the same rate as cholic acid, reabsorbed from the small intestine, and resecreted. It is not absorbed when the terminal ileum has been excised or bypassed. SeHCAT is therefore the first of a new class of radiopharmaceuticals, namely, gamma-emitting tracers of the complete cycle of the enterohepatic circulation. Its use will simplify investigation of the functional state of the terminal ileum by eliminating the need to collect and process feces.
- OSTI ID:
- 5478227
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 23:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BILE ACIDS
METABOLISM
RADIOPHARMACEUTICALS
CHEMICAL PROPERTIES
ABSORPTION
BLOOD CIRCULATION
CHOLIC ACID
EXCRETION
SELENIUM 75
BETA DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CLEARANCE
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
LABELLED COMPOUNDS
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
RADIOISOTOPES
SELENIUM ISOTOPES
STEROIDS
STEROLS
550601* - Medicine- Unsealed Radionuclides in Diagnostics