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Title: The oncogenic action of ionizing radiation on rat skin

Abstract

Progress is described in three areas corresponding to carcinogenesis and DNA strand breaks in rat skin following exposure by the neon ions or electrons; oncogene activation in radiation-induced rat skin cancers; and DNA strand breaks in the epidermis as a function of radiation penetration. Approximately 200 rats were exposed to the neon ion beam at the Bevalac in Berkeley, CA. The carcinogenicity of energetic electrons (2.0 Mev) was determined for comparison with the neon ion results. For double skin thickness irradiations electrons there was an unusually large excess of connective tissue tumors, fibromas and sarcomas. Presumably the latter tumors are occurring, because more connective tissue is exposed by deeply penetrating, i.e., energetic, beams. 13 refs.

Authors:
;
Publication Date:
Research Org.:
New York Univ., NY (USA). Dept. of Environmental Medicine
Sponsoring Org.:
DOE/ER
OSTI Identifier:
5473028
Report Number(s):
DOE/ER/60539-T1; COO-3380-60
ON: DE90001535; TRN: 89-028989
DOE Contract Number:  
FG02-87ER60539
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; NEOPLASMS; RADIOINDUCTION; ONCOGENES; GENE AMPLIFICATION; SKIN; BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL FUNCTIONS; BIOLOGICAL MODELS; CARCINOGENESIS; DNA; DOSE-RESPONSE RELATIONSHIPS; FORECASTING; IONIZING RADIATIONS; LET; PROGRESS REPORT; RADIATION PROTECTION; RATS; STRAND BREAKS; ANIMALS; BIOLOGICAL EFFECTS; BODY; DISEASES; DOCUMENT TYPES; ENERGY TRANSFER; FUNCTIONS; GENES; MAMMALS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANS; PATHOGENESIS; RADIATION EFFECTS; RADIATIONS; RODENTS; VERTEBRATES; 560120* - Radiation Effects on Biochemicals, Cells, & Tissue Culture; 550400 - Genetics

Citation Formats

Burns, F. J., and Garte, S. J. The oncogenic action of ionizing radiation on rat skin. United States: N. p., 1989. Web. doi:10.2172/5473028.
Burns, F. J., & Garte, S. J. The oncogenic action of ionizing radiation on rat skin. United States. https://doi.org/10.2172/5473028
Burns, F. J., and Garte, S. J. 1989. "The oncogenic action of ionizing radiation on rat skin". United States. https://doi.org/10.2172/5473028. https://www.osti.gov/servlets/purl/5473028.
@article{osti_5473028,
title = {The oncogenic action of ionizing radiation on rat skin},
author = {Burns, F. J. and Garte, S. J.},
abstractNote = {Progress is described in three areas corresponding to carcinogenesis and DNA strand breaks in rat skin following exposure by the neon ions or electrons; oncogene activation in radiation-induced rat skin cancers; and DNA strand breaks in the epidermis as a function of radiation penetration. Approximately 200 rats were exposed to the neon ion beam at the Bevalac in Berkeley, CA. The carcinogenicity of energetic electrons (2.0 Mev) was determined for comparison with the neon ion results. For double skin thickness irradiations electrons there was an unusually large excess of connective tissue tumors, fibromas and sarcomas. Presumably the latter tumors are occurring, because more connective tissue is exposed by deeply penetrating, i.e., energetic, beams. 13 refs.},
doi = {10.2172/5473028},
url = {https://www.osti.gov/biblio/5473028}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Sun Jan 01 00:00:00 EST 1989},
month = {Sun Jan 01 00:00:00 EST 1989}
}