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Title: Bioavailability of lead in rats fed human diets

Abstract

The bioavailability of lead was studied in rats fed various baby foods (Babymix-turkey, Babymix-vegetables, Frutolino-fruit, Frutamix-bananas, Babyron-S-26, Truefood), cow's milk, bread, liver and standard rat diet. Lead absorption was determined by measuring the whole body retention of /sup 203/Pb 6 days after a single oral application. Highest absorption values ranging from 17 to 20% were obtained in animals fed cow's milk and fruit foods. Rats on other human diets absorbed between 3 and 8% of the radioactive lead dose. Only in animals on rat diet lead absorption was below 1%. It is concluded that rats fed human diets show absorption values similar to those in humans. This might indicate that the bioavailability of lead is primarily dependent on dietary habits. This experimental model, if confirmed by further work, might be useful for obtaining preliminary data on the bioavailability of metals from various foods.

Authors:
;
Publication Date:
Research Org.:
Inst. for Medical Research and Occupational Health, Zagreb, Yugoslavia
OSTI Identifier:
5472994
Resource Type:
Journal Article
Journal Name:
Bull. Environ. Contam. Toxicol.; (United States)
Additional Journal Information:
Journal Volume: 21:3
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; DIET; BIOLOGICAL EFFECTS; LEAD; METABOLISM; LEAD 203; TRACER TECHNIQUES; RATS; TOLERANCE; BIOLOGICAL MODELS; COMPARATIVE EVALUATIONS; INTESTINAL ABSORPTION; MAN; RETENTION; TOXICITY; ANIMALS; BETA DECAY RADIOISOTOPES; DAYS LIVING RADIOISOTOPES; ELECTRON CAPTURE RADIOISOTOPES; ELEMENTS; EVEN-ODD NUCLEI; HEAVY NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; LEAD ISOTOPES; MAMMALS; METALS; NUCLEI; PRIMATES; RADIOISOTOPES; RODENTS; SECONDS LIVING RADIOISOTOPES; UPTAKE; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987); 550501 - Metabolism- Tracer Techniques

Citation Formats

Kostial, K., and Kello, D. Bioavailability of lead in rats fed human diets. United States: N. p., 1979. Web. doi:10.1007/BF01685428.
Kostial, K., & Kello, D. Bioavailability of lead in rats fed human diets. United States. doi:10.1007/BF01685428.
Kostial, K., and Kello, D. Thu . "Bioavailability of lead in rats fed human diets". United States. doi:10.1007/BF01685428.
@article{osti_5472994,
title = {Bioavailability of lead in rats fed human diets},
author = {Kostial, K. and Kello, D.},
abstractNote = {The bioavailability of lead was studied in rats fed various baby foods (Babymix-turkey, Babymix-vegetables, Frutolino-fruit, Frutamix-bananas, Babyron-S-26, Truefood), cow's milk, bread, liver and standard rat diet. Lead absorption was determined by measuring the whole body retention of /sup 203/Pb 6 days after a single oral application. Highest absorption values ranging from 17 to 20% were obtained in animals fed cow's milk and fruit foods. Rats on other human diets absorbed between 3 and 8% of the radioactive lead dose. Only in animals on rat diet lead absorption was below 1%. It is concluded that rats fed human diets show absorption values similar to those in humans. This might indicate that the bioavailability of lead is primarily dependent on dietary habits. This experimental model, if confirmed by further work, might be useful for obtaining preliminary data on the bioavailability of metals from various foods.},
doi = {10.1007/BF01685428},
journal = {Bull. Environ. Contam. Toxicol.; (United States)},
number = ,
volume = 21:3,
place = {United States},
year = {1979},
month = {2}
}