The hamster flank organ model: Is it relevant to man

Journal Article · Sun Oct 01 00:00:00 EDT 1989 · Journal of Investigative Dermatology; (USA)

DOI:https://doi.org/10.1111/1523-1747.ep12284038· OSTI ID:5468212

Franz, T J; Lehman, P A; Pochi, P; Odland, G F; Olerud, J ^[1]

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1. Univ. of Washington, Seattle (USA)

The critical role that androgens play in the etiology of acne has led to a search for topically active antiandrogens and the frequent use of the flank organ of the golden Syrian hamster as an animal model. 17-alpha-propyltestosterone (17-PT) has been identified as having potent antiandrogenic activity in the hamster model, and this report describes its clinical evaluation. Two double-blind placebo controlled studies comparing 4% 17-PT in 80% alcohol versus vehicle alone were conducted. One study examined 17-PT sebosuppressive activity in 20 subjects. The second study examined its efficacy in 44 subjects having mild to moderate acne. A third study measured in vitro percutaneous absorption of 17-PT through hamster flank and monkey skin, and human face skin in-vivo, using radioactive drug. 17-PT was found to be ineffective in reducing either the sebum excretion rate or the number of inflammatory acne lesions. Failure of 17-PT to show clinical activity was not a result of poor percutaneous absorption. Total absorption in man was 7.7% of the dose and only 1.0% in the hamster. The sebaceous gland of hamster flank organ is apparently more sensitive to antiandrogens than the human sebaceous gland.

• OSTI ID: 5468212
• Journal Information: Journal of Investigative Dermatology; (USA), Vol. 93:4; ISSN 0022-202X
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
SKIN DISEASES
ETIOLOGY
TESTOSTERONE
BIOLOGICAL FUNCTIONS
BIOLOGICAL MODELS
CARBON ISOTOPES
HAMSTERS
MAN
MONKEYS
SKIN ABSORPTION
TRACER TECHNIQUES
ABSORPTION
ANDROGENS
ANDROSTANES
ANIMALS
DISEASES
FUNCTIONS
HORMONES
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
ISOTOPES
KETONES
MAMMALS
ORGANIC COMPOUNDS
PRIMATES
RODENTS
STEROID HORMONES
STEROIDS
UPTAKE
VERTEBRATES
550901* - Pathology- Tracer Techniques