Induction of diphtheria toxin-resistant mutants in human cells by ultraviolet light
Journal Article
·
· Carcinogenesis (N.Y.); (United States)
Stable spontaneous mutants resistant to the protein synthesis inhibitor diphtheria toxin (DT) have been selected in human cell line EUE at a very low frequency (less than 8 x 10(-6)). U.v.-induced mutation has been quantitatively measured: treatment of cells with u.v. light increased the frequencies of diphtheria toxin resistant (DTr) mutants up to 1000-fold. The maximum recovery of DTr mutants was observed after a short expression period, for all u.v. doses tested, and was followed by a decrease in mutation frequency on subsequent passages.
- Research Organization:
- Istituto di Cancerologia, Universita di Bologna, Italy
- OSTI ID:
- 5463567
- Journal Information:
- Carcinogenesis (N.Y.); (United States), Vol. 2:12
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL RADIATION EFFECTS
SPONTANEOUS MUTATIONS
RADIOINDUCTION
DIPHTHERIA
DOSE-RESPONSE RELATIONSHIPS
MAN
MUTATION FREQUENCY
TOXINS
ULTRAVIOLET RADIATION
ANIMALS
ANTIGENS
BACTERIAL DISEASES
BIOLOGICAL EFFECTS
DISEASES
ELECTROMAGNETIC RADIATION
INFECTIOUS DISEASES
MAMMALS
MATERIALS
MUTATIONS
PRIMATES
RADIATION EFFECTS
RADIATIONS
TOXIC MATERIALS
VERTEBRATES
560121* - Radiation Effects on Cells- External Source- (-1987)
ANIMAL CELLS
BIOLOGICAL RADIATION EFFECTS
SPONTANEOUS MUTATIONS
RADIOINDUCTION
DIPHTHERIA
DOSE-RESPONSE RELATIONSHIPS
MAN
MUTATION FREQUENCY
TOXINS
ULTRAVIOLET RADIATION
ANIMALS
ANTIGENS
BACTERIAL DISEASES
BIOLOGICAL EFFECTS
DISEASES
ELECTROMAGNETIC RADIATION
INFECTIOUS DISEASES
MAMMALS
MATERIALS
MUTATIONS
PRIMATES
RADIATION EFFECTS
RADIATIONS
TOXIC MATERIALS
VERTEBRATES
560121* - Radiation Effects on Cells- External Source- (-1987)