Hepatic copper content in normal and toxic milk neonatal mice
Adult toxic milk mice exhibit over ten times normal amounts of hepatic copper. Patterns of hepatic copper accumulation were followed in neonates born both to normal (+/-/+/-, +/-/tx/-) and mutant (tx/-/tx/-) mothers. At birth all offspring of normal dams have high hepatic copper levels which then decline over the next two weeks; after this time levels in normal neonates continue to decline while in mutant neonates levels rise sharply, both genotypes attaining adult levels by six weeks. Conversely, all offspring of mutant females are born severely copper deficient, a condition exacerbated by ingestion of the copper deficient milk that these females produce, which leads to death during the second week. Such infants can be rescued if fostered to normal lactating females at birth; copper levels rise for two weeks and then fall in normal infants but continue to rise in mutant infants. Beginning at the third postnatal week then, hepatic copper levels are attributable to infant genotype, while prior to this time concentrations reflect maternal genotype. The pattern of uptake of /sup 67/Cu by neonates is consistent with the copper content observed above. Those hepatic cuproproteins which vary according to genotype also indicate that the third week is the time when infant genotype becomes expressed in phenotype. The significant accumulation of copper in the livers of fetuses carried by normal dams is compared to that occurring in the livers of suckling mutants.
- Research Organization:
- Univ. of Massachusetts, Amherst
- OSTI ID:
- 5461746
- Report Number(s):
- CONF-8604222-; TRN: 86-028422
- Journal Information:
- Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:3; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
COPPER
BIOLOGICAL ACCUMULATION
METABOLISM
COPPER 67
FETUSES
LIVER
MICE
MILK
MUTANTS
NEONATES
NUTRITIONAL DEFICIENCY
PHENOTYPE
PROGENY
TRACER TECHNIQUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
COPPER ISOTOPES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
ELEMENTS
FOOD
GLANDS
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
METALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
RODENTS
TRANSITION ELEMENTS
VERTEBRATES
550501* - Metabolism- Tracer Techniques