Postradiation atrophy of mature bone
The primary event of radiation damage to bone is atrophy and true necrosis of bone is uncommon. The postradiation atrophic changes of bone are the result of combined cellular and vascular damage, the former being more important. The damage to the osteoblast resulting in decreased matrix production is apparently the primary histopathologic event. Radiation damaged bone is susceptible to superimposed complications of fracture, infection, necrosis, and sarcoma. The primary radiographic evidence of atrophy, localized osteopenia, is late in appearing. Contrary to former views, the mature bone is quite radiosensitive and reacts quickly to even small doses of radiation. The differentiation of postirradiation atrophy and metastasis may be difficult. Biopsy should be the last resort because of the possibility of causing true necrosis in atrophic bone by trauma and infection.
- Research Organization:
- Aultman Hospital, Canton, OH
- OSTI ID:
- 5457561
- Journal Information:
- CRC Crit. Rev. Diagn. Imaging; (United States), Vol. 12:3
- Country of Publication:
- United States
- Language:
- English
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Postradiation atrophy of mature bone
Postradiation atrophy of mature bone
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62 RADIOLOGY AND NUCLEAR MEDICINE
ATROPHY
RADIOINDUCTION
BLOOD VESSELS
BIOLOGICAL RADIATION EFFECTS
BONE CELLS
BONE FRACTURES
OSTEORADIONECROSIS
RADIOTHERAPY
SIDE EFFECTS
SARCOMAS
SKELETON
METASTASES
PATIENTS
RADIOISOTOPE SCANNING
ANIMAL CELLS
BIOLOGICAL EFFECTS
BODY
CARDIOVASCULAR SYSTEM
CONNECTIVE TISSUE CELLS
COUNTING TECHNIQUES
DISEASES
INJURIES
LOCAL RADIATION EFFECTS
MEDICINE
NECROSIS
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIATION INJURIES
RADIOLOGY
SKELETAL DISEASES
SOMATIC CELLS
THERAPY
560151* - Radiation Effects on Animals- Man
550603 - Medicine- External Radiation in Therapy- (1980-)