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Title: Effect of hydrocortisone on radiosensitivity of hemopoietic stem cells. [. gamma. rays; mice; bone marrow; spleen]

Abstract

Studies were made of the direction of differentiation and radiosensitivity of CFU (colony-forming units) of bone marrow and spleen for 1 month after single injection of 5 mg hydrocortisone (HC) per mouse. It was found that there was a sharp change in direction of differentiation of CFU from different sources. Bone marrow CFU enhanced erythropoiesis and CFU of the spleen enhanced myelopoiesis, which is not inherent in the same CFU of normal mice. Determination of radiosensitivity of CFU from different sources according to the spleen colony test failed to demonstrate any differences in value of D/sub 0/ and extrapolation number, whereas substantial changes in radiosensitivity were demonstrated in the bone marrow colony test. Radiosensitivity of marrow CFU diminished while that of the spleen increased, as compared to the control. It is assumed that these phenomena are due to redistribution of T lymphocytes in response to HC.

Authors:
Publication Date:
OSTI Identifier:
5457476
Alternate Identifier(s):
OSTI ID: 5457476
Resource Type:
Journal Article
Journal Name:
Radiobiology (USSR) (Engl. Transl.); (United States)
Additional Journal Information:
Journal Volume: 18:4; Other Information: Translated from Radiobiologiya; 18: No. 4, 529-534(1978)
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CFU; RADIOSENSITIVITY; HYDROCORTISONE; RADIOSENSITIVITY EFFECTS; STEM CELLS; BIOLOGICAL RADIATION EFFECTS; BONE MARROW CELLS; CELL DIFFERENTIATION; CESIUM 137; COMPARATIVE EVALUATIONS; EXPERIMENTAL DATA; GAMMA RADIATION; IN VITRO; IRRADIATION; ISOLATED VALUES; LYMPHOCYTES; MICE; SPLEEN CELLS; ADRENAL HORMONES; ALKALI METAL ISOTOPES; ANIMAL CELLS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CESIUM ISOTOPES; CONNECTIVE TISSUE CELLS; CORTICOSTEROIDS; DATA; DATA FORMS; ELECTROMAGNETIC RADIATION; GLUCOCORTICOIDS; HORMONES; HYDROXY COMPOUNDS; INFORMATION; IONIZING RADIATIONS; ISOTOPES; KETONES; LEUKOCYTES; MAMMALS; MATERIALS; NUCLEI; NUMERICAL DATA; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; PREGNANES; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; RODENTS; SOMATIC CELLS; STEROID HORMONES; STEROIDS; VERTEBRATES; YEARS LIVING RADIOISOTOPES 560152* -- Radiation Effects on Animals-- Animals

Citation Formats

Shvets, V.N. Effect of hydrocortisone on radiosensitivity of hemopoietic stem cells. [. gamma. rays; mice; bone marrow; spleen]. United States: N. p., 1979. Web.
Shvets, V.N. Effect of hydrocortisone on radiosensitivity of hemopoietic stem cells. [. gamma. rays; mice; bone marrow; spleen]. United States.
Shvets, V.N. Thu . "Effect of hydrocortisone on radiosensitivity of hemopoietic stem cells. [. gamma. rays; mice; bone marrow; spleen]". United States.
@article{osti_5457476,
title = {Effect of hydrocortisone on radiosensitivity of hemopoietic stem cells. [. gamma. rays; mice; bone marrow; spleen]},
author = {Shvets, V.N.},
abstractNote = {Studies were made of the direction of differentiation and radiosensitivity of CFU (colony-forming units) of bone marrow and spleen for 1 month after single injection of 5 mg hydrocortisone (HC) per mouse. It was found that there was a sharp change in direction of differentiation of CFU from different sources. Bone marrow CFU enhanced erythropoiesis and CFU of the spleen enhanced myelopoiesis, which is not inherent in the same CFU of normal mice. Determination of radiosensitivity of CFU from different sources according to the spleen colony test failed to demonstrate any differences in value of D/sub 0/ and extrapolation number, whereas substantial changes in radiosensitivity were demonstrated in the bone marrow colony test. Radiosensitivity of marrow CFU diminished while that of the spleen increased, as compared to the control. It is assumed that these phenomena are due to redistribution of T lymphocytes in response to HC.},
doi = {},
journal = {Radiobiology (USSR) (Engl. Transl.); (United States)},
number = ,
volume = 18:4,
place = {United States},
year = {1979},
month = {3}
}