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Title: Bone tumors in Thorotrast patients. [Ra]

Abstract

Among the Thorotrast patients throughout the world, nine bone sarcomas (six histologically confirmed and three possible) were reported as of 1974. Their appearance times ranged from 16 to 33 years, averaging 26 years after Thorotrast injection. In some countries the population at risk is uncertain, but in Denmark, Germany, and Portugal, about 3000 patients have been followed more than 10 years (45,000 persons - years at risk beyond the first 10 years). In these 3000 patients, three to six bone sarcomas have occurred, compared with 0.5 case expected naturally. Using the dosimetric results of Rowland and Rundo and assuming the translocating /sup 224/Ra was mainly responsible, the provisional risk coefficient is 55 to 120 bone sarcomas/10/sup 6/ person - rad of actual dose to the skeleton without marrow. This risk coefficient is highly tentative because it is based on only three to six bone sarcomas, all reported since 1972. If additional bone sarcomas occur among the living Thorotrast patients, the risk coefficient could increase appreciably. For comparison, the risk coefficient for long protracted injections of /sup 224/Ra is about 200 bone sarcomas/10/sup 6/ person - rad, based on 54 cases of bone sarcoma.

Authors:
 [1];
  1. (Univ. of Utah, Salt Lake City)
Publication Date:
OSTI Identifier:
5457182
DOE Contract Number:  
EY-76-C-02-0119
Resource Type:
Journal Article
Journal Name:
Environ. Res.; (United States)
Additional Journal Information:
Journal Volume: 18:1
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; BONE TISSUES; DELAYED RADIATION EFFECTS; OSTEOSARCOMAS; RADIOINDUCTION; RADIUM 224; TOXICITY; THOROTRAST; DOSE-RESPONSE RELATIONSHIPS; LATENCY PERIOD; MEDICAL SURVEILLANCE; PATIENTS; TIME DEPENDENCE; ACTINIDE COMPOUNDS; ALKALINE EARTH ISOTOPES; ALPHA DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; CHALCOGENIDES; COLLOIDS; CONNECTIVE TISSUE; CONTRAST MEDIA; DAYS LIVING RADIOISOTOPES; DISEASES; DISPERSIONS; EVEN-EVEN NUCLEI; HEAVY NUCLEI; ISOTOPES; NEOPLASMS; NUCLEI; OXIDES; OXYGEN COMPOUNDS; RADIATION EFFECTS; RADIOCOLLOIDS; RADIOISOTOPES; RADIUM ISOTOPES; SARCOMAS; SKELETAL DISEASES; THORIUM COMPOUNDS; THORIUM OXIDES; TISSUES; 560171* - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987); 550601 - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Mays, C.W., and Spiess, H. Bone tumors in Thorotrast patients. [Ra]. United States: N. p., 1979. Web.
Mays, C.W., & Spiess, H. Bone tumors in Thorotrast patients. [Ra]. United States.
Mays, C.W., and Spiess, H. Thu . "Bone tumors in Thorotrast patients. [Ra]". United States.
@article{osti_5457182,
title = {Bone tumors in Thorotrast patients. [Ra]},
author = {Mays, C.W. and Spiess, H.},
abstractNote = {Among the Thorotrast patients throughout the world, nine bone sarcomas (six histologically confirmed and three possible) were reported as of 1974. Their appearance times ranged from 16 to 33 years, averaging 26 years after Thorotrast injection. In some countries the population at risk is uncertain, but in Denmark, Germany, and Portugal, about 3000 patients have been followed more than 10 years (45,000 persons - years at risk beyond the first 10 years). In these 3000 patients, three to six bone sarcomas have occurred, compared with 0.5 case expected naturally. Using the dosimetric results of Rowland and Rundo and assuming the translocating /sup 224/Ra was mainly responsible, the provisional risk coefficient is 55 to 120 bone sarcomas/10/sup 6/ person - rad of actual dose to the skeleton without marrow. This risk coefficient is highly tentative because it is based on only three to six bone sarcomas, all reported since 1972. If additional bone sarcomas occur among the living Thorotrast patients, the risk coefficient could increase appreciably. For comparison, the risk coefficient for long protracted injections of /sup 224/Ra is about 200 bone sarcomas/10/sup 6/ person - rad, based on 54 cases of bone sarcoma.},
doi = {},
journal = {Environ. Res.; (United States)},
number = ,
volume = 18:1,
place = {United States},
year = {1979},
month = {2}
}