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Title: Osteosarcoma induced by short-lived bone-seeking. cap alpha. emitters in mice: the role of age. [/sup 224/Ra, /sup 227/Th]

Abstract

In three experiments with low, medium, and high osteosarcoma expectancy after incorporation of /sup 224/Ra or /sup 227/Th the osteosarcoma risk of adult (5-6 months old) female NMRI mice was compared with that of rapid growing (1 month old) animals. Similar to results in the literature with other bone-seeking radionuclides the age-corrected osteosarcoma incidence was not significantly different in both age groups. In the experiment with high osteosarcoma risk the time of tumor appearance was mainly determined by the time of start of the internal irradiation period. It seems that at lower osteosarcoma expectancy the time of appearance of the tumors is mainly determined by the age of the animals.

Authors:
; ; ;
Publication Date:
Research Org.:
Gesellschaft fuer Strahlen- und Umweltforscung mbH, Neuherberg, Germany
OSTI Identifier:
5457039
Resource Type:
Journal Article
Journal Name:
Environ. Res.; (United States)
Additional Journal Information:
Journal Volume: 18:1
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; AGE GROUPS; RADIOSENSITIVITY EFFECTS; BONE TISSUES; BIOLOGICAL RADIATION EFFECTS; MICE; OSTEOSARCOMAS; RADIOINDUCTION; RADIUM 224; TOXICITY; THORIUM 227; BONE SEEKERS; COMPARATIVE EVALUATIONS; DOSE-RESPONSE RELATIONSHIPS; EXPECTATION VALUE; FRACTIONATED IRRADIATION; INTRAPERITONEAL INJECTION; LATENCY PERIOD; RADIONUCLIDE KINETICS; ACTINIDE ISOTOPES; ACTINIDE NUCLEI; ALKALINE EARTH ISOTOPES; ALPHA DECAY RADIOISOTOPES; ANIMALS; BIOLOGICAL EFFECTS; BODY; CONNECTIVE TISSUE; DAYS LIVING RADIOISOTOPES; DISEASES; EVEN-EVEN NUCLEI; EVEN-ODD NUCLEI; HEAVY NUCLEI; INJECTION; INTAKE; IRRADIATION; ISOTOPES; MAMMALS; NEOPLASMS; NUCLEI; RADIATION EFFECTS; RADIOISOTOPES; RADIUM ISOTOPES; RODENTS; SARCOMAS; SKELETAL DISEASES; THORIUM ISOTOPES; TISSUES; VERTEBRATES; 560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987); 550801 - Morphology- Tracer Techniques; 551001 - Physiological Systems- Tracer Techniques

Citation Formats

Luz, A., Mueller, W.A., Goessner, W., and Hug, O. Osteosarcoma induced by short-lived bone-seeking. cap alpha. emitters in mice: the role of age. [/sup 224/Ra, /sup 227/Th]. United States: N. p., 1979. Web.
Luz, A., Mueller, W.A., Goessner, W., & Hug, O. Osteosarcoma induced by short-lived bone-seeking. cap alpha. emitters in mice: the role of age. [/sup 224/Ra, /sup 227/Th]. United States.
Luz, A., Mueller, W.A., Goessner, W., and Hug, O. Thu . "Osteosarcoma induced by short-lived bone-seeking. cap alpha. emitters in mice: the role of age. [/sup 224/Ra, /sup 227/Th]". United States.
@article{osti_5457039,
title = {Osteosarcoma induced by short-lived bone-seeking. cap alpha. emitters in mice: the role of age. [/sup 224/Ra, /sup 227/Th]},
author = {Luz, A. and Mueller, W.A. and Goessner, W. and Hug, O.},
abstractNote = {In three experiments with low, medium, and high osteosarcoma expectancy after incorporation of /sup 224/Ra or /sup 227/Th the osteosarcoma risk of adult (5-6 months old) female NMRI mice was compared with that of rapid growing (1 month old) animals. Similar to results in the literature with other bone-seeking radionuclides the age-corrected osteosarcoma incidence was not significantly different in both age groups. In the experiment with high osteosarcoma risk the time of tumor appearance was mainly determined by the time of start of the internal irradiation period. It seems that at lower osteosarcoma expectancy the time of appearance of the tumors is mainly determined by the age of the animals.},
doi = {},
journal = {Environ. Res.; (United States)},
number = ,
volume = 18:1,
place = {United States},
year = {1979},
month = {2}
}