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Title: Comparative investigations on the biokinetics of colloidal thorium, zirconium, and hafnium dioxides in animals

Abstract

The aim of the investigations is to establish biophysical data as a basis for dose calculations of realized projected long-term animal experiments devoted to the problem radiation and nonradiation effect of Thorotrast. For this purpose a Thorotrast-equivalent thorium dioxide aquasol as well as dextrin-stabilized aquasols of zirconium and hafnium dioxides (Zirconotrast, Hafnorast) of our own production have been injected intravascularly into rats. The animals subdivided in four subgroups have been administered 60 to 600 ..mu..l of any colloid per rat. Four subgroups were sacrificed at different times between 1 and 100 days after injection. The whole-body kinetics of Thorotrast and Hafnotrast have been studied by single whole-body counting of altogether 10 animals during the total time of exposure. Both the distribution of the colloids and the activity ratios between /sup 232/Th and daughters have been determined. Supplementary to these investigations studies were performed on the Thorotrast kinetics in mice and in one dog.

Authors:
 [1]; ; ; ;
  1. (Freie Universitaet, Berlin, Germany)
Publication Date:
OSTI Identifier:
5457026
Resource Type:
Journal Article
Journal Name:
Environ. Res.; (United States)
Additional Journal Information:
Journal Volume: 18:1
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; DOGS; BIOLOGICAL RADIATION EFFECTS; HAFNIUM OXIDES; RADIONUCLIDE KINETICS; MICE; RATS; RETICULOENDOTHELIAL SYSTEM; THOROTRAST; ZIRCONIUM OXIDES; BIOCHEMICAL REACTION KINETICS; BODY BURDEN; COMPARATIVE EVALUATIONS; EXPERIMENTAL DATA; INTRAVENOUS INJECTION; ISOLATED VALUES; RADIATION DOSES; TISSUE DISTRIBUTION; ACTINIDE COMPOUNDS; ANIMALS; BIOLOGICAL EFFECTS; BODY; CHALCOGENIDES; COLLOIDS; CONTRAST MEDIA; DATA; DATA FORMS; DISPERSIONS; DISTRIBUTION; DOSES; HAFNIUM COMPOUNDS; INFORMATION; INJECTION; INTAKE; KINETICS; MAMMALS; NUMERICAL DATA; OXIDES; OXYGEN COMPOUNDS; RADIATION EFFECTS; RADIOCOLLOIDS; REACTION KINETICS; RODENTS; THORIUM COMPOUNDS; THORIUM OXIDES; TISSUES; TRANSITION ELEMENT COMPOUNDS; VERTEBRATES; ZIRCONIUM COMPOUNDS; 560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987); 550601 - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Riedel, W., Hirschberg, R., Kaul, A., Schmier, H., and Walter, U. Comparative investigations on the biokinetics of colloidal thorium, zirconium, and hafnium dioxides in animals. United States: N. p., 1979. Web. doi:10.1016/0013-9351(79)90146-4.
Riedel, W., Hirschberg, R., Kaul, A., Schmier, H., & Walter, U. Comparative investigations on the biokinetics of colloidal thorium, zirconium, and hafnium dioxides in animals. United States. doi:10.1016/0013-9351(79)90146-4.
Riedel, W., Hirschberg, R., Kaul, A., Schmier, H., and Walter, U. Thu . "Comparative investigations on the biokinetics of colloidal thorium, zirconium, and hafnium dioxides in animals". United States. doi:10.1016/0013-9351(79)90146-4.
@article{osti_5457026,
title = {Comparative investigations on the biokinetics of colloidal thorium, zirconium, and hafnium dioxides in animals},
author = {Riedel, W. and Hirschberg, R. and Kaul, A. and Schmier, H. and Walter, U.},
abstractNote = {The aim of the investigations is to establish biophysical data as a basis for dose calculations of realized projected long-term animal experiments devoted to the problem radiation and nonradiation effect of Thorotrast. For this purpose a Thorotrast-equivalent thorium dioxide aquasol as well as dextrin-stabilized aquasols of zirconium and hafnium dioxides (Zirconotrast, Hafnorast) of our own production have been injected intravascularly into rats. The animals subdivided in four subgroups have been administered 60 to 600 ..mu..l of any colloid per rat. Four subgroups were sacrificed at different times between 1 and 100 days after injection. The whole-body kinetics of Thorotrast and Hafnotrast have been studied by single whole-body counting of altogether 10 animals during the total time of exposure. Both the distribution of the colloids and the activity ratios between /sup 232/Th and daughters have been determined. Supplementary to these investigations studies were performed on the Thorotrast kinetics in mice and in one dog.},
doi = {10.1016/0013-9351(79)90146-4},
journal = {Environ. Res.; (United States)},
number = ,
volume = 18:1,
place = {United States},
year = {1979},
month = {2}
}