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Title: Effect of restricted maternal zinc intake on zinc absorption in infant rhesus monkeys

Abstract

One compensatory mechanism for marginal Zn intake may be enhanced absorption of Zn. While there is some experimental evidence to support this hypothesis from rodent models, there are few data from higher mammalian species. Such a compensatory mechanism of enhanced Zn absorption could be of value to the neonate, as poor Zn nutriture during early life has severe consequences on growth and development. The authors have investigated the absorption of Zn by infant Rhesus monkeys born to control and Zn-restricted mothers. Fasted infant monkeys (100 d) from mothers fed a 100 or 4 ppm Zn diet were intubated with an infant formula containing Zn-65. Whole body radioactivity was counted immediately after intubation and on days 10 and 17 post-intubation. Day 10 data were used to calculate apparent absorption values. Regardless of dietary group, apparent Zn absorption as high, ranging from 30-60% of the dose fed. While there was not a marked difference between the two groups in the groups in the dose absorbed, an inverse correlation was noted between infant body weight and Zn absorption. An inverse correlation was found for plasma Zn concentration and apparent Zn absorption. These results suggest that body weight and plasma Zn level, as relatedmore » to Zn status and growth rate, may be predictors of Zn absorption.« less

Authors:
; ; ; ; ; ;
Publication Date:
Research Org.:
Univ. of California, Davis
OSTI Identifier:
5456361
Report Number(s):
CONF-8604222-
Journal ID: CODEN: FEPRA; TRN: 86-028583
Resource Type:
Conference
Journal Name:
Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
Additional Journal Information:
Journal Volume: 45:3; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; ZINC; BIOLOGICAL EFFECTS; INTESTINAL ABSORPTION; ANIMAL GROWTH; MONKEYS; NEONATES; TRACER TECHNIQUES; WEIGHT; ZINC 65; ABSORPTION; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; DAYS LIVING RADIOISOTOPES; ELECTRON CAPTURE RADIOISOTOPES; ELEMENTS; EVEN-ODD NUCLEI; GROWTH; INTERMEDIATE MASS NUCLEI; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; METALS; NUCLEI; PRIMATES; RADIOISOTOPES; UPTAKE; VERTEBRATES; ZINC ISOTOPES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987); 550501 - Metabolism- Tracer Techniques

Citation Formats

Loennerdal, B, Keen, C L, Bell, J G, Golub, M, Gershwin, M E, Hurley, L s, and Hendrickx, A G. Effect of restricted maternal zinc intake on zinc absorption in infant rhesus monkeys. United States: N. p., 1986. Web.
Loennerdal, B, Keen, C L, Bell, J G, Golub, M, Gershwin, M E, Hurley, L s, & Hendrickx, A G. Effect of restricted maternal zinc intake on zinc absorption in infant rhesus monkeys. United States.
Loennerdal, B, Keen, C L, Bell, J G, Golub, M, Gershwin, M E, Hurley, L s, and Hendrickx, A G. Sat . "Effect of restricted maternal zinc intake on zinc absorption in infant rhesus monkeys". United States.
@article{osti_5456361,
title = {Effect of restricted maternal zinc intake on zinc absorption in infant rhesus monkeys},
author = {Loennerdal, B and Keen, C L and Bell, J G and Golub, M and Gershwin, M E and Hurley, L s and Hendrickx, A G},
abstractNote = {One compensatory mechanism for marginal Zn intake may be enhanced absorption of Zn. While there is some experimental evidence to support this hypothesis from rodent models, there are few data from higher mammalian species. Such a compensatory mechanism of enhanced Zn absorption could be of value to the neonate, as poor Zn nutriture during early life has severe consequences on growth and development. The authors have investigated the absorption of Zn by infant Rhesus monkeys born to control and Zn-restricted mothers. Fasted infant monkeys (100 d) from mothers fed a 100 or 4 ppm Zn diet were intubated with an infant formula containing Zn-65. Whole body radioactivity was counted immediately after intubation and on days 10 and 17 post-intubation. Day 10 data were used to calculate apparent absorption values. Regardless of dietary group, apparent Zn absorption as high, ranging from 30-60% of the dose fed. While there was not a marked difference between the two groups in the groups in the dose absorbed, an inverse correlation was noted between infant body weight and Zn absorption. An inverse correlation was found for plasma Zn concentration and apparent Zn absorption. These results suggest that body weight and plasma Zn level, as related to Zn status and growth rate, may be predictors of Zn absorption.},
doi = {},
url = {https://www.osti.gov/biblio/5456361}, journal = {Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)},
number = ,
volume = 45:3,
place = {United States},
year = {1986},
month = {3}
}

Conference:
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