skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: The ''hot spleen'' phenomenon in metastatic malignant melanoma: its incidence and relationship with the immune system

Abstract

Of patients with Stage II and III malignant melanoma, 34.7% display reversal of the liver-spleen ratio on technetium-99m-sulfhur colloid isotope scans. Such an occurrence does not suggest a greater likelihood of relapse or a worse survival. The phenomenom is more common in female patients and there is a significant relationship between the presence of a ''hot spleen'' and a high IgM level. Patients with Stage II disease and high IgM levels have relapses more quickly than do those with normal IgM levels. Lymphopenia is common in patients with Stage II and III disease and the survival of these patients is worse than that of those with normal lymphocyte counts. In this report, the data are discussed together with results from other investigations, and a unifying hypothesis is presented which explains the phenomenon and relates it to increased activity of macrophages as a result of the presence of the tumor. The usefulness of isotope liver scanning in stage III malignant melanoma is also discussed.

Authors:
; ; ; ;
Publication Date:
Research Org.:
Department of Medical Oncology, Christie Hospital, Manchester, England
OSTI Identifier:
5450999
Resource Type:
Journal Article
Journal Name:
Cancer (Philadelphia); (United States)
Additional Journal Information:
Journal Volume: 49:3
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; NEOPLASMS; DIAGNOSIS; SPLEEN; RADIOISOTOPE SCANNING; BACTERIA; ISOMERIC NUCLEI; LIVER; MALES; MAN; MELANOMAS; PATIENTS; SEX DEPENDENCE; TECHNETIUM 99; VACCINES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; COUNTING TECHNIQUES; DIGESTIVE SYSTEM; DISEASES; GLANDS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MICROORGANISMS; NUCLEI; ODD-EVEN NUCLEI; ORGANS; PRIMATES; RADIOISOTOPES; TECHNETIUM ISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Wagstaff, J., Phadke, K., Adam, N., Thatcher, N., and Crowther, D. The ''hot spleen'' phenomenon in metastatic malignant melanoma: its incidence and relationship with the immune system. United States: N. p., 1982. Web. doi:10.1002/1097-0142(19820201)49:3<439::AID-CNCR2820490308>3.0.CO;2-U.
Wagstaff, J., Phadke, K., Adam, N., Thatcher, N., & Crowther, D. The ''hot spleen'' phenomenon in metastatic malignant melanoma: its incidence and relationship with the immune system. United States. doi:10.1002/1097-0142(19820201)49:3<439::AID-CNCR2820490308>3.0.CO;2-U.
Wagstaff, J., Phadke, K., Adam, N., Thatcher, N., and Crowther, D. Mon . "The ''hot spleen'' phenomenon in metastatic malignant melanoma: its incidence and relationship with the immune system". United States. doi:10.1002/1097-0142(19820201)49:3<439::AID-CNCR2820490308>3.0.CO;2-U.
@article{osti_5450999,
title = {The ''hot spleen'' phenomenon in metastatic malignant melanoma: its incidence and relationship with the immune system},
author = {Wagstaff, J. and Phadke, K. and Adam, N. and Thatcher, N. and Crowther, D.},
abstractNote = {Of patients with Stage II and III malignant melanoma, 34.7% display reversal of the liver-spleen ratio on technetium-99m-sulfhur colloid isotope scans. Such an occurrence does not suggest a greater likelihood of relapse or a worse survival. The phenomenom is more common in female patients and there is a significant relationship between the presence of a ''hot spleen'' and a high IgM level. Patients with Stage II disease and high IgM levels have relapses more quickly than do those with normal IgM levels. Lymphopenia is common in patients with Stage II and III disease and the survival of these patients is worse than that of those with normal lymphocyte counts. In this report, the data are discussed together with results from other investigations, and a unifying hypothesis is presented which explains the phenomenon and relates it to increased activity of macrophages as a result of the presence of the tumor. The usefulness of isotope liver scanning in stage III malignant melanoma is also discussed.},
doi = {10.1002/1097-0142(19820201)49:3<439::AID-CNCR2820490308>3.0.CO;2-U},
journal = {Cancer (Philadelphia); (United States)},
number = ,
volume = 49:3,
place = {United States},
year = {1982},
month = {2}
}