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Title: Platelet interaction within giant intracranial aneurysms

Abstract

Turbulence within intracranial aneurysms may result in tearing of the aneurysmal wall, exposing the subendothelial matrix to circulating platelets. In this study, platelet interaction in giant intracranial aneurysms was evaluated by a dual-isotope technique employing In-labeled platelets and Tc-labeled red blood cells. The use of two isotopes allows the subtraction of the blood pool and the calculation of the ratio indium deposited:indium blood pool (In(D)/In(BP)). A ratio greater than zero indicates platelet deposition within aneurysm. Thirteen patients were evaluated in this way, with platelet deposition demonstrated in six. In these six patients, the ratio In(D)/In(BP) was found to be significantly elevated, with a mean value of 0.96 +/- 0.65. Three of these six patients has symptoms of recurrent transient neurological deficits; one of these three suffered a complete stroke following documentation of platelet deposition. In this case, the aneurysm was obtained at surgery and was found to contain intraluminal platelet aggregation when viewed by scanning electron microscopy. In the remaining seven patients, the ratio IN(D)/In(BP) was found not to be significantly elevated (mean -0.03 and/- 0.06), indicating the absence of active platelet deposition. Two of these patients had prior symptoms of cerebral ischemia; one of these was found to havemore » an ulcer in the ipsilateral internal carotid artery which was probably responsible for thromboembolic events to the hemisphere. The authors conclude that platelet aggregation occurs more frequently than previously recognized in giant intracranial aneurysms, and their data substantiate the hypothesis that platelet metabolic products or thrombi originating from a large aneurysm may embolize to distal cerebral vessels.« less

Authors:
; ; ; ; ;
Publication Date:
Research Org.:
Department of Clinical Neurological Sciences (Division of Neurosurgery), University of Western Ontario, London, Canada
OSTI Identifier:
5450893
Resource Type:
Journal Article
Journal Name:
J. Neurosurg.; (United States)
Additional Journal Information:
Journal Volume: 56:1
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; INDIUM 111; DUAL-ISOTOPE SUBTRACTION TECHNIQUE; TECHNETIUM 99; VASCULAR DISEASES; DIAGNOSIS; PATHOLOGY; BLOOD PLATELETS; ERYTHROCYTES; ISOMERIC NUCLEI; LABELLED COMPOUNDS; PATIENTS; SKULL; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; DAYS LIVING RADIOISOTOPES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; HOURS LIVING RADIOISOTOPES; INDIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MATERIALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPES; SKELETON; TECHNETIUM ISOTOPES; TRACER TECHNIQUES; YEARS LIVING RADIOISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 550901 - Pathology- Tracer Techniques; 551001 - Physiological Systems- Tracer Techniques

Citation Formats

Sutherland, G R, King, M E, Peerless, S J, Vezina, W C, Brown, G W, and Chamberlain, M J. Platelet interaction within giant intracranial aneurysms. United States: N. p., 1982. Web. doi:10.3171/jns.1982.56.1.0053.
Sutherland, G R, King, M E, Peerless, S J, Vezina, W C, Brown, G W, & Chamberlain, M J. Platelet interaction within giant intracranial aneurysms. United States. doi:10.3171/jns.1982.56.1.0053.
Sutherland, G R, King, M E, Peerless, S J, Vezina, W C, Brown, G W, and Chamberlain, M J. Fri . "Platelet interaction within giant intracranial aneurysms". United States. doi:10.3171/jns.1982.56.1.0053.
@article{osti_5450893,
title = {Platelet interaction within giant intracranial aneurysms},
author = {Sutherland, G R and King, M E and Peerless, S J and Vezina, W C and Brown, G W and Chamberlain, M J},
abstractNote = {Turbulence within intracranial aneurysms may result in tearing of the aneurysmal wall, exposing the subendothelial matrix to circulating platelets. In this study, platelet interaction in giant intracranial aneurysms was evaluated by a dual-isotope technique employing In-labeled platelets and Tc-labeled red blood cells. The use of two isotopes allows the subtraction of the blood pool and the calculation of the ratio indium deposited:indium blood pool (In(D)/In(BP)). A ratio greater than zero indicates platelet deposition within aneurysm. Thirteen patients were evaluated in this way, with platelet deposition demonstrated in six. In these six patients, the ratio In(D)/In(BP) was found to be significantly elevated, with a mean value of 0.96 +/- 0.65. Three of these six patients has symptoms of recurrent transient neurological deficits; one of these three suffered a complete stroke following documentation of platelet deposition. In this case, the aneurysm was obtained at surgery and was found to contain intraluminal platelet aggregation when viewed by scanning electron microscopy. In the remaining seven patients, the ratio IN(D)/In(BP) was found not to be significantly elevated (mean -0.03 and/- 0.06), indicating the absence of active platelet deposition. Two of these patients had prior symptoms of cerebral ischemia; one of these was found to have an ulcer in the ipsilateral internal carotid artery which was probably responsible for thromboembolic events to the hemisphere. The authors conclude that platelet aggregation occurs more frequently than previously recognized in giant intracranial aneurysms, and their data substantiate the hypothesis that platelet metabolic products or thrombi originating from a large aneurysm may embolize to distal cerebral vessels.},
doi = {10.3171/jns.1982.56.1.0053},
journal = {J. Neurosurg.; (United States)},
number = ,
volume = 56:1,
place = {United States},
year = {1982},
month = {1}
}