Field size dependence of radiation sensitivity and dose fractionation response in skin

Journal Article · Sat Jun 01 00:00:00 EDT 1985 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(85)90062-8· OSTI ID:5444730

Shymko, R M; Hauser, D L; Archambeau, J O

Four sets of data from the literature were analyzed to assess the effects of field size on dose tolerance and dose fraction size dependence in irradiated skin. The data consisted of combinations of total dose and dose per exposure (or number of fractions) required to yield a given degree of visible damage to the skin, for fields of different sizes. Putative cell survival curves were constructed, under the assumptions that the isoeffect represents a fixed cell survival, and that each exposure during a course of fractionated irradiation has equal effect on cell survival. The analysis showed that 1) overall sensitivity to radiation, and 2) dependence on dose per exposure, both increase with field size. To account for these results the authors describe a model that can be qualitatively related to the geometric properties of the dermal vascular network. The model predicts a greater fractionation sensitivity in large than in small fields, in agreement with our analysis of the isoeffect data. It is therefore possible that the advantages of hyperfractionation in reducing late effects in normal tissues may be related to vascular architecture, to inherent differences between late and acutely responding cell populations.

• Research Organization: City of Hope Medical Center, Duarte, CA
• OSTI ID: 5444730
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 11:6
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BLOOD VESSELS
BIOLOGICAL RADIATION EFFECTS
RADIOSENSITIVITY
MATHEMATICAL MODELS
SKIN
FRACTIONATED IRRADIATION
MAN
MICE
RADIOTHERAPY
SURVIVAL CURVES
SWINE
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARDIOVASCULAR SYSTEM
DOMESTIC ANIMALS
IRRADIATION
MAMMALS
MEDICINE
NUCLEAR MEDICINE
ORGANS
PRIMATES
RADIATION EFFECTS
RADIOLOGY
RODENTS
THERAPY
VERTEBRATES
560151* - Radiation Effects on Animals- Man
560152 - Radiation Effects on Animals- Animals