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Title: Total skin electron beam and total nodal irradiation for treatment of patients with cutaneous T-cell lymphoma

Abstract

Sixteen patients with advanced cutaneous T-cell lymphoma (CTCL) with or without lymph node involvement, but without evidence of extranodal manifestations, were treated with a combination of total skin electron beam therapy (TSEB) and total nodal irradiation (TNI). Fourteen (87%) patients achieved a complete response (CR) lasting from 1 to 84+ months (median, 8+ months) from the completion of treatment. The best results occurred in 6 patients with pretumorous intracutaneous CTCL (Stages IB and IIA) where the CR has lasted in all patients from 8 to 84+ months (median about 27+ months). Radiotherapy was well tolerated with the major toxicity being bone marrow suppression. The authors conclude that combined TSEB and TNI is a relatively safe and effective treatment for patients with CTCL prior to the development of lymph node involvement. Long-term follow-up is needed to assess the curative potential of this treatment.

Authors:
; ; ;
Publication Date:
Research Org.:
Hahnemann Univ., Philadelphia, PA
OSTI Identifier:
5436583
Resource Type:
Journal Article
Journal Name:
Int. J. Radiat. Oncol., Biol. Phys.; (United States)
Additional Journal Information:
Journal Volume: 11:6
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; BONE MARROW; BIOLOGICAL RADIATION EFFECTS; HERPES SIMPLEX; RADIOINDUCTION; HERPES ZOSTER; IMMUNOSUPPRESSION; RADIOTHERAPY; SIDE EFFECTS; SKIN; THYROID; ELECTRON BEAMS; LYMPH NODES; LYMPHOMAS; PARTIAL BODY IRRADIATION; PATIENTS; RADIODERMATITIS; ANIMAL TISSUES; BEAMS; BIOLOGICAL EFFECTS; BODY; DERMATITIS; DISEASES; ENDOCRINE GLANDS; EXTERNAL IRRADIATION; GLANDS; HEMATOPOIETIC SYSTEM; INFECTIOUS DISEASES; INJURIES; IRRADIATION; LEPTON BEAMS; LOCAL RADIATION EFFECTS; LYMPHATIC SYSTEM; MEDICINE; NEOPLASMS; NERVOUS SYSTEM DISEASES; NUCLEAR MEDICINE; ORGANS; PARTICLE BEAMS; RADIATION EFFECTS; RADIATION INJURIES; RADIOLOGY; SKIN DISEASES; THERAPY; TISSUES; VIRAL DISEASES; 560151* - Radiation Effects on Animals- Man; 550603 - Medicine- External Radiation in Therapy- (1980-)

Citation Formats

Micaily, B, Vonderheid, E C, Brady, L W, and Andrews, C. Total skin electron beam and total nodal irradiation for treatment of patients with cutaneous T-cell lymphoma. United States: N. p., 1985. Web. doi:10.1016/0360-3016(85)90057-4.
Micaily, B, Vonderheid, E C, Brady, L W, & Andrews, C. Total skin electron beam and total nodal irradiation for treatment of patients with cutaneous T-cell lymphoma. United States. https://doi.org/10.1016/0360-3016(85)90057-4
Micaily, B, Vonderheid, E C, Brady, L W, and Andrews, C. 1985. "Total skin electron beam and total nodal irradiation for treatment of patients with cutaneous T-cell lymphoma". United States. https://doi.org/10.1016/0360-3016(85)90057-4.
@article{osti_5436583,
title = {Total skin electron beam and total nodal irradiation for treatment of patients with cutaneous T-cell lymphoma},
author = {Micaily, B and Vonderheid, E C and Brady, L W and Andrews, C},
abstractNote = {Sixteen patients with advanced cutaneous T-cell lymphoma (CTCL) with or without lymph node involvement, but without evidence of extranodal manifestations, were treated with a combination of total skin electron beam therapy (TSEB) and total nodal irradiation (TNI). Fourteen (87%) patients achieved a complete response (CR) lasting from 1 to 84+ months (median, 8+ months) from the completion of treatment. The best results occurred in 6 patients with pretumorous intracutaneous CTCL (Stages IB and IIA) where the CR has lasted in all patients from 8 to 84+ months (median about 27+ months). Radiotherapy was well tolerated with the major toxicity being bone marrow suppression. The authors conclude that combined TSEB and TNI is a relatively safe and effective treatment for patients with CTCL prior to the development of lymph node involvement. Long-term follow-up is needed to assess the curative potential of this treatment.},
doi = {10.1016/0360-3016(85)90057-4},
url = {https://www.osti.gov/biblio/5436583}, journal = {Int. J. Radiat. Oncol., Biol. Phys.; (United States)},
number = ,
volume = 11:6,
place = {United States},
year = {Sat Jun 01 00:00:00 EDT 1985},
month = {Sat Jun 01 00:00:00 EDT 1985}
}