Studies of skeletal tracer kinetics. II. Evaluation of a five-compartment model of (/sup 18/F)fluoride kinetics in rats
We have evaluated a five-compartment model of (/sup 18/F)fluoride kinetics in rats. The initial fluoride distribution was found to be similar to that of (/sup 77/Br)bromide, a known extracellular-fluid (ECF) tracer, in agreement with the hypothesis underlying the model, and the measured uptake rate in rat bones compared well with the digital computer solution. Simpler models did not give a better fit. In dead rats, fluoride movement was found within the skeleton, presumably from bone ECF to bone substance, although not as rapidly as predicted or found in the live animal. Evaluation of the rate constants permitted estimates to be made of cardiac output, skeletal blood flow, and bone ECF volume, all in accord with independent measurements. It is suggested that skeletal blood flow at rest is a constant fraction of body weight, and probably subserves a hematopoietic as well as a mineralization function.
- Research Organization:
- Temple Univ. School of Medicine, Philadelphia, PA
- OSTI ID:
- 5432724
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 20:11
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
FLUORINE 18
RADIONUCLIDE KINETICS
RATS
RADIOSENSITIVITY
SKELETON
BIOLOGICAL MODELS
BLOOD FLOW
BROMINE 77
COMPARATIVE EVALUATIONS
EXPERIMENTAL DATA
ISOLATED VALUES
MATHEMATICAL MODELS
MORTALITY
TIME DEPENDENCE
TRACER TECHNIQUES
UPTAKE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BROMINE ISOTOPES
DATA
DATA FORMS
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
FLUORINE ISOTOPES
HOURS LIVING RADIOISOTOPES
INFORMATION
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIOISOTOPES
RODENTS
VERTEBRATES
560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)
550601 - Medicine- Unsealed Radionuclides in Diagnostics