Offspring of female brindled mice fed a copper-deficient diet develop anemia
Female C57BL mice heterozygous for the brindled gene (Mo/sup br/+/) were mated to normal males and fed a purified diet low in copper(-Cu)(0.5 ppm), modified AIN-76A, throughout gestation and lactation to investigate copper-dependent anemia. Half the females were given deionized water and half copper-supplemented water (20 ppm Cu as CuSO/sub 4/). Four groups of 12 day old male offspring were compared (Dunn-Bonferroni t-test ..cap alpha.. = 0.05): I = +Cu(Mo/sup +/y/), II = -Cu(Mo/sup +/y/), III = +Cu(Mo/sup br/y/), IV = -Cu(Mo/sup br/y/). Offspring in I and III were equivalent to those in earlier studies when dams were fed Mouse-Chow. Liver Cu levels in I are below normal. Compared to III the mice in IV were smaller and had lower hematocrits, however, liver Cu and Fe levels were similar. Liver superoxide dismutase (SOD) activity was lower in IV compared to III. Compared to II, mice in IV were smaller and thus had higher hematocrits and liver Fe. Liver Cu and SOD activities were similar but plasma ceruloplasmin activities were higher in IV. Offspring of brindled female mice exhibit lower liver copper levels compared to offspring from normal females. This is true whether dams are fed a nonpurified diet or the -Cu diet with or without a Cu supplement in the water. Thus, all offspring of brindled dams have abnormal copper homeostasis during perinatal development. When copper is limiting brindled mice will develop anemia.
- Research Organization:
- Univ. of Minnesota, Duluth
- OSTI ID:
- 5431139
- Report Number(s):
- CONF-8604222-
- Journal Information:
- Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:3; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
COPPER
BIOLOGICAL EFFECTS
NUTRITIONAL DEFICIENCY
SUPEROXIDE DISMUTASE
ENZYME ACTIVITY
ANEMIAS
BLOOD COUNT
CERULOPLASMIN
DIET
LACTATION
LIVER
MICE
PREGNANCY
ANIMALS
BODY
COMPLEXES
COPPER COMPLEXES
DIGESTIVE SYSTEM
DISEASES
ELEMENTS
ENZYMES
GLANDS
GLOBULINS
GLOBULINS-ALPHA
HEMIC DISEASES
MAMMALS
METALLOPROTEINS
METALS
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
PROTEINS
RODENTS
SYMPTOMS
TRANSITION ELEMENT COMPLEXES
TRANSITION ELEMENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)