(Regulation of terpene metabolism). Progress report. [Mentha piperita]
Studies on the regulation of monoterpene metabolism in M. piperita were conducted. All of the steps from the acyclic precursor geranyl pyrophosphate to the various menthol isomers have been demonstrated. The first intermediate to accumulate in vivo is d-pulegone. The emphasis has been on the demonstration, partial purification and characterization of the relevant enzymes in the pathway. The studies on the isopiperitenol dehydrogenase and isopiperitenone isomerase have been completed. We are not studying the endocyclic double-bond reductase (NADPH-dependent) and, based on substrate specificity studies and the previously demonstrated isomerization of cis- isopulegone to pulegone, are now virtually convinced that the major pathway to menthol(s) in peppermint involves reduction of isopiperitenone to isopulegone and isomerication of isopulegone to pulegone. 16 refs., 1 fig.
- Research Organization:
- Washington State Univ., Pullman (USA). Inst. of Biological Chemistry
- DOE Contract Number:
- AT06-82ER12027
- OSTI ID:
- 5426270
- Report Number(s):
- DOE/ER/12027-4; ON: DE86015255
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
TERPENES
METABOLISM
BIOLOGICAL PATHWAYS
ELECTRON MICROSCOPY
LEAVES
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MICROSCOPY
ORGANIC COMPOUNDS
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550501 - Metabolism- Tracer Techniques