Genetic and developmental study of a complex locus in the house mouse. Progress report, August 1, 1978-June 1, 1979
More than 50 T/t-complex and other mouse chromosome variants are being maintained for genetic study and for distribution to other investigators. Mapping experiments within a viable t-haplotype have been completed, and show conclusively that this variant virtually completely suppresses recombination for three centimorgans distal to itself, but enhances recombination in a 4 centimorgan region distal to that. Complementation tests of a new lethal t-haplotype, t/sup w//sup 75/, which have shown that it contains two lethal factors characteristic of both the t/sup wl/ and the t/sup w/sup 5// complementation groups have been completed. Deletion mapping has been used to study transmission ratio distortion, and these experiments show clearly that a gene or genes on the chromosome homologous to the t-bearing one have a pronounced effect in governing the degree of distortion. Other experiments to extract and analyze t-haplotypes from wild populations are continuing, as in the analysis of viable recombinant t-variants produced by existing lethal t-haplotypes.
- Research Organization:
- Sloan-Kettering Inst. for Cancer Research, New York (USA)
- DOE Contract Number:
- AC02-77EV04159
- OSTI ID:
- 5415071
- Report Number(s):
- COO-4159-5
- Country of Publication:
- United States
- Language:
- English
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Genetic and developmental study of a complex locus in the house mouse
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