skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Regional cerebral blood flow measurement with intravenous ( sup 15 O)water bolus and ( sup 18 F)fluoromethane inhalation

Abstract

In 20 patients with ischemic cerebrovascular disease, classic migraine, or angiomas, we compared paired dynamic positron emission tomographic measurements of regional cerebral blood flow using both ({sup 15}O)water and ({sup 18}F)fluoromethane as tracers. Cerebral blood flow was also determined according to the autoradiographic technique with a bolus injection of ({sup 15}O)water. There were reasonable overall correlations between dynamic ({sup 15}O)water and ({sup 18}F)fluoromethane values for cerebral blood flow (r = 0.82) and between dynamic and autoradiographic ({sup 15}O)water values for cerebral blood flow (r = 0.83). We found a close correspondence between abnormal pathologic findings and visually evaluated cerebral blood flow tomograms obtained with the two tracers. On average, dynamic ({sup 15}O)water cerebral blood flow was 6% lower than that measured with ({sup 18}F)fluoromethane. There also was a general trend toward a greater underestimation with ({sup 15}O)water in high-flow areas, particularly in hyperemic areas, probably due to incomplete first-pass extraction of ({sup 15}O)water. Underestimation was not detected in low-flow areas or in the cerebellum. Absolute cerebral blood flow values were less closely correlated between tracers and techniques than cerebral blood flow patterns. The variability of the relation between absolute flow values was probably caused by confounding effects of the variationmore » in the circulatory delay time. The autoradiographic technique was most sensitive to this type error.« less

Authors:
; ; ; ; ; ; ; ;  [1]
  1. (Max-Planck-Institut fuer neurologische Forschung, Koeln (Germany, F.R.))
Publication Date:
OSTI Identifier:
5411359
Resource Type:
Journal Article
Journal Name:
Stroke; (USA)
Additional Journal Information:
Journal Volume: 20:9; Journal ID: ISSN 0039-2499
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CEREBRAL CORTEX; BLOOD FLOW; ISCHEMIA; DIAGNOSIS; AUTORADIOGRAPHY; DATA COVARIANCES; FLUORINE 18; OXYGEN 15; PATIENTS; POSITRON COMPUTED TOMOGRAPHY; WATER; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; BRAIN; CARDIOVASCULAR DISEASES; CENTRAL NERVOUS SYSTEM; CEREBRUM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; EMISSION COMPUTED TOMOGRAPHY; EVEN-ODD NUCLEI; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; HYDROGEN COMPOUNDS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; MINUTES LIVING RADIOISOTOPES; NERVOUS SYSTEM; NUCLEI; ODD-ODD NUCLEI; ORGANS; OXYGEN COMPOUNDS; OXYGEN ISOTOPES; RADIOISOTOPES; TOMOGRAPHY; VASCULAR DISEASES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Herholz, K., Pietrzyk, U., Wienhard, K., Hebold, I., Pawlik, G., Wagner, R., Holthoff, V., Klinkhammer, P., and Heiss, W.D. Regional cerebral blood flow measurement with intravenous ( sup 15 O)water bolus and ( sup 18 F)fluoromethane inhalation. United States: N. p., 1989. Web. doi:10.1161/01.STR.20.9.1174.
Herholz, K., Pietrzyk, U., Wienhard, K., Hebold, I., Pawlik, G., Wagner, R., Holthoff, V., Klinkhammer, P., & Heiss, W.D. Regional cerebral blood flow measurement with intravenous ( sup 15 O)water bolus and ( sup 18 F)fluoromethane inhalation. United States. doi:10.1161/01.STR.20.9.1174.
Herholz, K., Pietrzyk, U., Wienhard, K., Hebold, I., Pawlik, G., Wagner, R., Holthoff, V., Klinkhammer, P., and Heiss, W.D. Fri . "Regional cerebral blood flow measurement with intravenous ( sup 15 O)water bolus and ( sup 18 F)fluoromethane inhalation". United States. doi:10.1161/01.STR.20.9.1174.
@article{osti_5411359,
title = {Regional cerebral blood flow measurement with intravenous ( sup 15 O)water bolus and ( sup 18 F)fluoromethane inhalation},
author = {Herholz, K. and Pietrzyk, U. and Wienhard, K. and Hebold, I. and Pawlik, G. and Wagner, R. and Holthoff, V. and Klinkhammer, P. and Heiss, W.D.},
abstractNote = {In 20 patients with ischemic cerebrovascular disease, classic migraine, or angiomas, we compared paired dynamic positron emission tomographic measurements of regional cerebral blood flow using both ({sup 15}O)water and ({sup 18}F)fluoromethane as tracers. Cerebral blood flow was also determined according to the autoradiographic technique with a bolus injection of ({sup 15}O)water. There were reasonable overall correlations between dynamic ({sup 15}O)water and ({sup 18}F)fluoromethane values for cerebral blood flow (r = 0.82) and between dynamic and autoradiographic ({sup 15}O)water values for cerebral blood flow (r = 0.83). We found a close correspondence between abnormal pathologic findings and visually evaluated cerebral blood flow tomograms obtained with the two tracers. On average, dynamic ({sup 15}O)water cerebral blood flow was 6% lower than that measured with ({sup 18}F)fluoromethane. There also was a general trend toward a greater underestimation with ({sup 15}O)water in high-flow areas, particularly in hyperemic areas, probably due to incomplete first-pass extraction of ({sup 15}O)water. Underestimation was not detected in low-flow areas or in the cerebellum. Absolute cerebral blood flow values were less closely correlated between tracers and techniques than cerebral blood flow patterns. The variability of the relation between absolute flow values was probably caused by confounding effects of the variation in the circulatory delay time. The autoradiographic technique was most sensitive to this type error.},
doi = {10.1161/01.STR.20.9.1174},
journal = {Stroke; (USA)},
issn = {0039-2499},
number = ,
volume = 20:9,
place = {United States},
year = {1989},
month = {9}
}