sup 111 In-labeled nonspecific immunoglobulin scanning in the detection of focal infection

Journal Article · Thu Oct 05 00:00:00 EDT 1989 · New England Journal of Medicine; (USA)

DOI:https://doi.org/10.1056/NEJM198910053211404· OSTI ID:5411169

Rubin, R H; Fischman, A J; Callahan, R J; Khaw, B A; Keech, F; Ahmad, M; Wilkinson, R; Strauss, H W ^[1]

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1. Massachusetts General Hospital, Boston (USA)

We performed radionuclide scanning after the intravenous injection of human IgG labeled with indium-111 in 128 patients with suspected focal sites of inflammation. Localization of 111In-labeled IgG correlated with clinical findings in 51 infected patients (21 with abdominal or pelvic infections, 11 with intravascular infections, 7 with pulmonary infections, and 12 with skeletal infections). Infecting organisms included gram-positive bacteria, gram-negative bacteria, Pneumocystis carinii, Mycoplasma pneumoniae, and Candida albicans. No focal localization of 111In-labeled IgG was observed in 63 patients without infection. There were five false negative results, and nine results were unusable. Serial scans were carried out in eight patients: continued localization correctly predicted relapse in six, and the absence of localization indicated resolution in two. To determine whether 111In-labeled IgG localization was specific for inflammation, we studied 16 patients with cancer. Focal localization occurred in 13 of these patients (5 with melanomas, 5 with gynecologic cancers, and 1 each with lymphoma, prostate cancer, and malignant fibrous histiocytoma). No localization was seen in patients with renal or colon cancer or metastatic medullary carcinoma of the thyroid. We conclude that 111In-labeled IgG imaging is effective for the detection of focal infection and that serial scans may be useful in assessing therapeutic efficacy. This technique may also be helpful in the evaluation of certain cancers.

• OSTI ID: 5411169
• Journal Information: New England Journal of Medicine; (USA), Vol. 321:14; ISSN 0028-4793
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
IMMUNOGLOBULINS
BIOLOGICAL LOCALIZATION
INFECTIOUS DISEASES
DIAGNOSIS
NEOPLASMS
ACCURACY
BACTERIA
CANDIDA
INDIUM 111
INFLAMMATION
LABELLING
MAN
MYCOPLASMA
PATIENTS
RADIOISOTOPE SCANNING
ANIMALS
BETA DECAY RADIOISOTOPES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EUMYCOTA
FUNGI
GLOBULINS
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MICROORGANISMS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
PLANTS
PRIMATES
PROTEINS
RADIOISOTOPES
SYMPTOMS
VERTEBRATES
YEASTS
550601* - Medicine- Unsealed Radionuclides in Diagnostics