Nuclear magnetic resonance contrast agents
This invention relates to the field of nuclear magnetic resonance imaging and nuclear magnetic resonance spectroscopy, also known simply as magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). MRI and MRS are particularly useful in medical research and diagnosis. MRI may be used in addition to x-ray imaging. This invention concerns a family of contrast agents for use in magnetic resonance imaging and a method of enhancing the contrast of magnetic resonance images of an object by incorporating a contrast agent of this invention into the object prior to forming the images or during formation of the images. A contrast agent of this invention is a paramagnetic lanthanide hexaazamacrocyclic molecule, where a basic example has the formula LnC{sub 16}H{sub 14}N{sub 6}. Important applications of the invention are in medical diagnosis, treatment, and research, where images of portions of a human body are formed by means of magnetic resonance techniques. 2 figs.
- Research Organization:
- Los Alamos National Lab., NM (United States)
- Sponsoring Organization:
- USDOE; USDOE, Washington, DC (United States)
- DOE Contract Number:
- W-7405-ENG-36
- Assignee:
- Dept. of Energy
- Patent Number(s):
- PATENTS-US-A7301678
- Application Number:
- ON: DE91016889; PPN: US 7-301678
- OSTI ID:
- 5408240
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
CONTRAST MEDIA
MAGNETIC PROPERTIES
NMR IMAGING
RARE EARTHS
BIOMEDICAL RADIOGRAPHY
CARBON COMPOUNDS
GADOLINIUM COMPOUNDS
HYDROGEN COMPOUNDS
INVENTIONS
NITROGEN COMPOUNDS
NUCLEAR MAGNETIC RESONANCE
PROTONS
SOLUTIONS
BARYONS
DIAGNOSTIC TECHNIQUES
DISPERSIONS
ELEMENTARY PARTICLES
ELEMENTS
FERMIONS
HADRONS
MAGNETIC RESONANCE
MEDICINE
METALS
MIXTURES
NUCLEAR MEDICINE
NUCLEONS
PHYSICAL PROPERTIES
RADIOLOGY
RARE EARTH COMPOUNDS
RESONANCE
360104* - Metals & Alloys- Physical Properties
560000 - Biomedical Sciences
Applied Studies
400201 - Chemical & Physicochemical Properties