Effect of ozone on the agglutination of erythrocytes by concanavalin A. I. Studies in rats. [Rats, tritium]
A decrease in the agglutination of rat erythrocytes by the lectin concanavalin A was observed after in vitro exposure to ozone (1 ppM for 2 h) and after inhalation of 0.5 to 2.0 ppM ozone for 2 h. Agglutination was inhibited by ..cap alpha..-methyl-D-mannopyrannoside demonstrating that it is specific for the lectin. Studies with radioactive concanavalin A indicated that ozone exposure did not significantly affect the number of membrane sites available for lectin binding. Further studies revealed that erythrocytes incubated with malonaldehyde, a decomposition product of lipid peroxidation, also showed a decrease in agglutination as did erythrocytes obtained from rats injected with the oxidizing agent, acetylphenylhydrazine. These findings are consistent with a possible causal role for malonaldehyde in mediating extrapulmonary effects observed after ozone exposure.
- Research Organization:
- New York Univ. Medical Center, NY
- OSTI ID:
- 5406940
- Journal Information:
- Environ. Res.; (United States), Vol. 19:2
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
TOXICITY
HYDRAZIDES
OZONE
RATS
TOLERANCE
ANTIGEN-ANTIBODY REACTIONS
BIOLOGICAL EFFECTS
DOSES
ERYTHROCYTES
INCUBATION
INHALATION
LECITHINS
LUNGS
MEMBRANES
TRACER TECHNIQUES
TRITIUM
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
ESTERS
HYDROGEN ISOTOPES
INTAKE
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
LIPIDS
MAMMALS
MATERIALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PHOSPHOLIPIDS
RADIOISOTOPES
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550201 - Biochemistry- Tracer Techniques
551001 - Physiological Systems- Tracer Techniques