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Title: Influence of dietary vitamin E on the red cells of ozone-exposed rats

Abstract

The effect of dietary vitamin E on the susceptibility of red blood cells to ozone exposure was studied in rats. One- and two-month-old male Sprague-Dawley rats were fed a basal vitamin E-deficient diet with or without 45 ppM vitamin E for 4 and 3 months, respectively, and were exposed to 0 or 0.8 ppM ozone continuously for 7 days. Ozone exposure resulted in a significant increase in the activities of glutathione (GSH) peroxidase, pyruvate kinase, and lactate dehydrogenase, and a decrease in GSH level in the red cells of vitamin E-deficient rats, but not in those of the supplemented group. The activities of glucose-6-phosphate dehydrogenase, catalase, and superoxide dismutase and levels of thiobarbituric acid reactants, methemoglobin, hemoglobin, and reticulocytes were not significantly altered by ozone exposure or by the nutritional status of vitamin E. The results suggest that depletion of dietary vitamin E renders animals more susceptible to ozone exposure.

Authors:
 [1];
  1. Univ. of Kentucky, Lexington
Publication Date:
OSTI Identifier:
5406843
Resource Type:
Journal Article
Journal Name:
Environ. Res.; (United States)
Additional Journal Information:
Journal Volume: 19:1
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; BIOCHEMICAL REACTION KINETICS; BIOLOGICAL EFFECTS; ERYTHROCYTES; OZONE; TOXICITY; RATS; TOLERANCE; VITAMIN E; RESPONSE MODIFYING FACTORS; CATALYSIS; ENZYMES; EXPERIMENTAL DATA; ISOLATED VALUES; METABOLISM; NUTRITIONAL DEFICIENCY; ANIMALS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; DATA; DATA FORMS; INFORMATION; KINETICS; MAMMALS; MATERIALS; NUMERICAL DATA; REACTION KINETICS; RODENTS; VERTEBRATES; VITAMINS; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987); 550200 - Biochemistry

Citation Formats

Chow, C K, and Kaneko, J J. Influence of dietary vitamin E on the red cells of ozone-exposed rats. United States: N. p., 1979. Web. doi:10.1016/0013-9351(79)90033-1.
Chow, C K, & Kaneko, J J. Influence of dietary vitamin E on the red cells of ozone-exposed rats. United States. https://doi.org/10.1016/0013-9351(79)90033-1
Chow, C K, and Kaneko, J J. Fri . "Influence of dietary vitamin E on the red cells of ozone-exposed rats". United States. https://doi.org/10.1016/0013-9351(79)90033-1.
@article{osti_5406843,
title = {Influence of dietary vitamin E on the red cells of ozone-exposed rats},
author = {Chow, C K and Kaneko, J J},
abstractNote = {The effect of dietary vitamin E on the susceptibility of red blood cells to ozone exposure was studied in rats. One- and two-month-old male Sprague-Dawley rats were fed a basal vitamin E-deficient diet with or without 45 ppM vitamin E for 4 and 3 months, respectively, and were exposed to 0 or 0.8 ppM ozone continuously for 7 days. Ozone exposure resulted in a significant increase in the activities of glutathione (GSH) peroxidase, pyruvate kinase, and lactate dehydrogenase, and a decrease in GSH level in the red cells of vitamin E-deficient rats, but not in those of the supplemented group. The activities of glucose-6-phosphate dehydrogenase, catalase, and superoxide dismutase and levels of thiobarbituric acid reactants, methemoglobin, hemoglobin, and reticulocytes were not significantly altered by ozone exposure or by the nutritional status of vitamin E. The results suggest that depletion of dietary vitamin E renders animals more susceptible to ozone exposure.},
doi = {10.1016/0013-9351(79)90033-1},
url = {https://www.osti.gov/biblio/5406843}, journal = {Environ. Res.; (United States)},
number = ,
volume = 19:1,
place = {United States},
year = {1979},
month = {6}
}