Homozygous deletion of the. alpha. - and. beta. sub 1 -interferon genes in human leukemia and derived cell lines

Journal Article · Fri Jul 01 00:00:00 EDT 1988 · Proceedings of the National Academy of Sciences of the United States of America; (USA)

DOI:https://doi.org/10.1073/pnas.85.14.5259· OSTI ID:5404644

Diaz, M O; Ziemin, S; Le Beau, M M; Pitha, P; Smith, S D; Chilcote, R R; Rowley, J D ^[1]

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1. Univ. of Chicago, IL (USA)

The loss of bands p21-22 from one chromosome 9 homologue as a consequence of a deletion of the short arm (del(9p)), unbalanced translocation, or monosomy 9 is frequently observed in the malignant cells of patients with lymphoid neoplasias, including acute lymphoblastic leukemia and non-Hodgkin lymphoma. The {alpha}- and {beta}{sub 1}-interferon genes have been assigned to this chromosome region (9p21-22). The authors now present evidence of the homozygous deletion of the interferon genes in neoplastic hematopoietic cell lines and primary leukemia cells in the presence or absence of chromosomal deletions that are detectable at the level of the light microscope. In these cell lines, the deletion of the interferon genes is accompanied by a deficiency of 5{prime}-methylthioadenosine phosphorylase, an enzyme of purine metabolism. These homozygous deletions may be associated with the loss of a tumor-suppressor gene that is involved in the development of these neoplasias. The relevant genes may be either the interferon genes themselves or a gene that has a tumor-suppressor function and is closely linked to them.

• OSTI ID: 5404644
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (USA), Vol. 85:14; ISSN 0027-8424
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
GLYCOSYL TRANSFERASES
BIOCHEMISTRY
INTERFERON
GENE MUTATIONS
CHROMOSOMAL ABERRATIONS
GENE REPRESSORS
GENES
HETEROCHROMOSOMES
HYBRIDIZATION
KARYOTYPE
LYMPHOMAS
PATIENTS
PLACENTA
TUMOR CELLS
ANIMAL CELLS
CHEMISTRY
CHROMOSOMES
DISEASES
ENZYMES
FETAL MEMBRANES
GROWTH FACTORS
IMMUNE SYSTEM DISEASES
LYMPHOKINES
MEMBRANES
MITOGENS
MUTATIONS
NEOPLASMS
NUCLEOPROTEINS
ORGANIC COMPOUNDS
PROTEINS
TRANSFERASES
550401* - Genetics- Tracer Techniques