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Title: Detection and cellular localization of lead by electron probe analysis in the diagnosis of suspected lead poisoning in rhesus monkeys

Abstract

Lead poisoning of unknown source was diagnosed histologically in 2 rhesus monkeys (Macaca mulatta) by finding acid-fast intranuclear inclusion bodies in the epithelial cells of renal cortical tubules. The presence of lead in the inclusions was determined by scanning electron microscopy/energy dispersive x-ray analysis using sections from paraffin embedded tissues. This observation indicates the usefulness of this technique for the detection and cellular localization of lead in tissues, even from archival material.

Authors:
; ;  [1]
  1. Division of Cancer Etiology, National Cancer Institute, Bethesda, Maryland (USA)
Publication Date:
OSTI Identifier:
5394911
Resource Type:
Journal Article
Journal Name:
Toxicologic Pathology; (United States)
Additional Journal Information:
Journal Volume: 19:1; Journal ID: ISSN 0192-6233
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; LEAD; TOXICITY; ELECTRON MICROPROBE ANALYSIS; EPITHELIUM; METABOLISM; MONKEYS; SCANNING ELECTRON MICROSCOPY; TISSUE DISTRIBUTION; TUBULES; ANIMAL TISSUES; ANIMALS; BODY; CHEMICAL ANALYSIS; DISTRIBUTION; ELECTRON MICROSCOPY; ELEMENTS; KIDNEYS; MAMMALS; METALS; MICROANALYSIS; MICROSCOPY; NONDESTRUCTIVE ANALYSIS; ORGANS; PRIMATES; TISSUES; VERTEBRATES; 560300* - Chemicals Metabolism & Toxicology; 550602 - Medicine- External Radiation in Diagnostics- (1980-)

Citation Formats

Sass, B, Banfield, W G, and Saffiotti, U. Detection and cellular localization of lead by electron probe analysis in the diagnosis of suspected lead poisoning in rhesus monkeys. United States: N. p., 1991. Web.
Sass, B, Banfield, W G, & Saffiotti, U. Detection and cellular localization of lead by electron probe analysis in the diagnosis of suspected lead poisoning in rhesus monkeys. United States.
Sass, B, Banfield, W G, and Saffiotti, U. Tue . "Detection and cellular localization of lead by electron probe analysis in the diagnosis of suspected lead poisoning in rhesus monkeys". United States.
@article{osti_5394911,
title = {Detection and cellular localization of lead by electron probe analysis in the diagnosis of suspected lead poisoning in rhesus monkeys},
author = {Sass, B and Banfield, W G and Saffiotti, U},
abstractNote = {Lead poisoning of unknown source was diagnosed histologically in 2 rhesus monkeys (Macaca mulatta) by finding acid-fast intranuclear inclusion bodies in the epithelial cells of renal cortical tubules. The presence of lead in the inclusions was determined by scanning electron microscopy/energy dispersive x-ray analysis using sections from paraffin embedded tissues. This observation indicates the usefulness of this technique for the detection and cellular localization of lead in tissues, even from archival material.},
doi = {},
journal = {Toxicologic Pathology; (United States)},
issn = {0192-6233},
number = ,
volume = 19:1,
place = {United States},
year = {1991},
month = {1}
}