A precision flow-controlled Rb-82 generator for bolus or constant-infusion studies of the heart and brain
A precision flow-controlled rubidium-82 generator has been constructed to deliver 76-sec Rb-82 at either fast or slow flow rates for bolus or constant-infusion studies. A stepping motor drive is interfaced to a microprocessor for pulsed control of flow rate to deliver the saline eluant solution from a large-volume (150 ml) machined pumping syringe through an alumina column that retains the 25-day Sr-82 parent. The generator system delivers 70-90% of the maximum Rb-82 activity in a 20-25 ml bolus elution of 2% NaCl. The Sr-82/Sr-85 breakthrough is 10(-7) - 10(-6). both yield and breakthrough are functions of column length and flow rate. Six separate Sr-82 loadings of the generator were evaluated over a period of nearly 2 yr in studies of myocardial blood perfusion and permeability changes in the blood-brain barrier. Sterility and apyrogenicity of the Rb-82 eluate were maintained during multiple elutions and long-term use of 3-4 mo for each generator loading.
- Research Organization:
- Donner Laboratory, University of California, Berkeley
- OSTI ID:
- 5393524
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 22:11
- Country of Publication:
- United States
- Language:
- English
Similar Records
Evaluation and application of alumina-based Rb-82 generators charged with high levels of Sr-82/85
.sup.82 Sr-.sup.82 Rb Radioisotope generator
Related Subjects
59 BASIC BIOLOGICAL SCIENCES
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
BRAIN
SCINTISCANNING
MYOCARDIUM
RADIOISOTOPE GENERATORS
DESIGN
RUBIDIUM 82
ISOTOPE APPLICATIONS
BLOOD-BRAIN BARRIER
CHEMICAL PREPARATION
PERFUSED TISSUES
STRONTIUM 82
ALKALI METAL ISOTOPES
ALKALINE EARTH ISOTOPES
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-EVEN NUCLEI
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOTOPES
MINUTES LIVING RADIOISOTOPES
MUSCLES
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RUBIDIUM ISOTOPES
STRONTIUM ISOTOPES
SYNTHESIS
TISSUES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
551001 - Physiological Systems- Tracer Techniques
400702 - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials