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Title: Statistical analysis of Japanese Thorotrast-administered autopsy cases

Abstract

The causes of death of 144 Japanese autopsy cases during 1945-1975, who had been intravascularly injected with Thorotrast in life, were compared with those of non-Thorotrast-administered autopsy cases in the same age bracket, recorded in the Annals of Japanese Pathological Autopsy Cases during 1958-1973. This comparison revealed that the incidence of malignant hepatic tumors was more than 10 times higher in the Thorotrast-administered cases. The increase was attributable to an increased incidence of hemangioendothelioma and cholangiocarcinoma of the liver. The only significant increase of liver cirrhosis found to exist in the Thorotrast group occurred in the female cases. Some of the Thorotrast-administered cases were found to have developed myeloid leukemia and erythroleukemia. There was also a significant increase in the number of cases of aplastic anemia in the Thorotrast group, but clinically and pathologically these were atypical. Lymphatic leukemia was not observed. No significant difference was found in the incidence of either malignant lymphomas or osteosarcomas in the Thorotrast group and the controls. Lung cancer, on the other hand, showed a significantly higher incidence among the controls than among the Thorotrast-administered cases.

Authors:
 [1]; ; ;
  1. (Kanagawa Prefectural Coll. of Nursing and Medical Tech., Nakoa, Japan)
Publication Date:
OSTI Identifier:
5388387
Resource Type:
Journal Article
Journal Name:
Environ. Res.; (United States)
Additional Journal Information:
Journal Volume: 18:1
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; 99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE; ANEMIAS; RADIOINDUCTION; BLOOD PLASMA; DELAYED RADIATION EFFECTS; HEPATOMAS; LIVER; LIVER CIRRHOSIS; MYELOID LEUKEMIA; THOROTRAST; SIDE EFFECTS; AUTOPSY; COMPARATIVE EVALUATIONS; JAPAN; PATIENTS; RADIONUCLIDE ADMINISTRATION; STATISTICS; ACTINIDE COMPOUNDS; ASIA; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BLOOD; BODY; BODY FLUIDS; CHALCOGENIDES; COLLOIDS; CONTRAST MEDIA; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; DIGESTIVE SYSTEM DISEASES; DISEASES; DISPERSIONS; GLANDS; HEMIC DISEASES; LEUKEMIA; MATERIALS; MATHEMATICS; NEOPLASMS; ORGANS; OXIDES; OXYGEN COMPOUNDS; RADIATION EFFECTS; RADIOCOLLOIDS; SYMPTOMS; THORIUM COMPOUNDS; THORIUM OXIDES; 560161* - Radionuclide Effects, Kinetics, & Toxicology- Man; 550601 - Medicine- Unsealed Radionuclides in Diagnostics; 552000 - Public Health

Citation Formats

Mori, T., Kato, Y., Shimamine, T., and Watanabe, S. Statistical analysis of Japanese Thorotrast-administered autopsy cases. United States: N. p., 1979. Web. doi:10.1016/0013-9351(79)90157-9.
Mori, T., Kato, Y., Shimamine, T., & Watanabe, S. Statistical analysis of Japanese Thorotrast-administered autopsy cases. United States. doi:10.1016/0013-9351(79)90157-9.
Mori, T., Kato, Y., Shimamine, T., and Watanabe, S. Thu . "Statistical analysis of Japanese Thorotrast-administered autopsy cases". United States. doi:10.1016/0013-9351(79)90157-9.
@article{osti_5388387,
title = {Statistical analysis of Japanese Thorotrast-administered autopsy cases},
author = {Mori, T. and Kato, Y. and Shimamine, T. and Watanabe, S.},
abstractNote = {The causes of death of 144 Japanese autopsy cases during 1945-1975, who had been intravascularly injected with Thorotrast in life, were compared with those of non-Thorotrast-administered autopsy cases in the same age bracket, recorded in the Annals of Japanese Pathological Autopsy Cases during 1958-1973. This comparison revealed that the incidence of malignant hepatic tumors was more than 10 times higher in the Thorotrast-administered cases. The increase was attributable to an increased incidence of hemangioendothelioma and cholangiocarcinoma of the liver. The only significant increase of liver cirrhosis found to exist in the Thorotrast group occurred in the female cases. Some of the Thorotrast-administered cases were found to have developed myeloid leukemia and erythroleukemia. There was also a significant increase in the number of cases of aplastic anemia in the Thorotrast group, but clinically and pathologically these were atypical. Lymphatic leukemia was not observed. No significant difference was found in the incidence of either malignant lymphomas or osteosarcomas in the Thorotrast group and the controls. Lung cancer, on the other hand, showed a significantly higher incidence among the controls than among the Thorotrast-administered cases.},
doi = {10.1016/0013-9351(79)90157-9},
journal = {Environ. Res.; (United States)},
number = ,
volume = 18:1,
place = {United States},
year = {1979},
month = {2}
}