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Title: Pathological changes of lymph nodes in Thorotrast patients: pathoanatomical, autoradiographical, and quantitative investigations

Abstract

38 postmortem cases and 120 lymph nodes taken from various regions of the body were studied and investigated. The liver and spleen of all the cases and thorotrastomas of six cases were also investigated. All 38 patients had suffered from thorotrastosis and died approximately 28 years after the injection. Paraffin sections, autoradiography, and neutron activation analysis were used. In lymph nodes, the mean concentration of Th-232 is higher than in the liver; it is, however, a little lower than in the spleen. The highest concentration of Th-232 is measured in the lymph nodes of the liver hilus, those in the area behind the pancreas, and around the hilus of the spleen. Lower concentrations are measured in the lymph nodes around the bifurcatio aortae, around the hilus of the lung, and in the groin. The contrast medium is deposited in small concentrations in the sinuses of the lymph nodes without showing any vital reaction in the surrounding area. Th-232 is stored only in a few reticulum cells. The follicles are free of Th-232. In lymph nodes with a higher concentration of Th-232, a strong fibrosis can be seen, occluding the lymph vessels. Spleen and thorotrastomas show a similar fibrosis to thatmore » seen in the lymph nodes. A large number of carcinomas and sarcomas of the liver were found. No malignant growth is seen in either lymph nodes, spleen, or thorotrastoma. In the final section of the paper the special localization of tumors in human thorotrastosis is considered.« less

Authors:
;
Publication Date:
Research Org.:
Municipal Hospital of Ludwigshafen, Ludwigshafen/Rhein, Germany
OSTI Identifier:
5388187
Resource Type:
Journal Article
Journal Name:
Environ. Res.; (United States)
Additional Journal Information:
Journal Volume: 18:1
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; FIBROSIS; RADIOINDUCTION; LIVER; DELAYED RADIATION EFFECTS; LYMPH NODES; SPLEEN; THORIUM 232; TISSUE DISTRIBUTION; THOROTRAST; SIDE EFFECTS; AGGLOMERATION; EXPERIMENTAL DATA; ISOLATED VALUES; PATIENTS; RADIONUCLIDE KINETICS; ACTINIDE COMPOUNDS; ACTINIDE ISOTOPES; ACTINIDE NUCLEI; ALPHA DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; CHALCOGENIDES; COLLOIDS; CONTRAST MEDIA; DATA; DATA FORMS; DIGESTIVE SYSTEM; DISEASES; DISPERSIONS; DISTRIBUTION; EVEN-EVEN NUCLEI; GLANDS; HEAVY NUCLEI; INFORMATION; ISOTOPES; LYMPHATIC SYSTEM; NUCLEI; NUMERICAL DATA; ORGANS; OXIDES; OXYGEN COMPOUNDS; PATHOLOGICAL CHANGES; RADIATION EFFECTS; RADIOCOLLOIDS; RADIOISOTOPES; THORIUM COMPOUNDS; THORIUM ISOTOPES; THORIUM OXIDES; YEARS LIVING RADIOISOTOPES; 560171* - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987); 560161 - Radionuclide Effects, Kinetics, & Toxicology- Man; 550601 - Medicine- Unsealed Radionuclides in Diagnostics; 550900 - Pathology

Citation Formats

Wegener, K., and Wesch, H. Pathological changes of lymph nodes in Thorotrast patients: pathoanatomical, autoradiographical, and quantitative investigations. United States: N. p., 1979. Web. doi:10.1016/0013-9351(79)90158-0.
Wegener, K., & Wesch, H. Pathological changes of lymph nodes in Thorotrast patients: pathoanatomical, autoradiographical, and quantitative investigations. United States. doi:10.1016/0013-9351(79)90158-0.
Wegener, K., and Wesch, H. Thu . "Pathological changes of lymph nodes in Thorotrast patients: pathoanatomical, autoradiographical, and quantitative investigations". United States. doi:10.1016/0013-9351(79)90158-0.
@article{osti_5388187,
title = {Pathological changes of lymph nodes in Thorotrast patients: pathoanatomical, autoradiographical, and quantitative investigations},
author = {Wegener, K. and Wesch, H.},
abstractNote = {38 postmortem cases and 120 lymph nodes taken from various regions of the body were studied and investigated. The liver and spleen of all the cases and thorotrastomas of six cases were also investigated. All 38 patients had suffered from thorotrastosis and died approximately 28 years after the injection. Paraffin sections, autoradiography, and neutron activation analysis were used. In lymph nodes, the mean concentration of Th-232 is higher than in the liver; it is, however, a little lower than in the spleen. The highest concentration of Th-232 is measured in the lymph nodes of the liver hilus, those in the area behind the pancreas, and around the hilus of the spleen. Lower concentrations are measured in the lymph nodes around the bifurcatio aortae, around the hilus of the lung, and in the groin. The contrast medium is deposited in small concentrations in the sinuses of the lymph nodes without showing any vital reaction in the surrounding area. Th-232 is stored only in a few reticulum cells. The follicles are free of Th-232. In lymph nodes with a higher concentration of Th-232, a strong fibrosis can be seen, occluding the lymph vessels. Spleen and thorotrastomas show a similar fibrosis to that seen in the lymph nodes. A large number of carcinomas and sarcomas of the liver were found. No malignant growth is seen in either lymph nodes, spleen, or thorotrastoma. In the final section of the paper the special localization of tumors in human thorotrastosis is considered.},
doi = {10.1016/0013-9351(79)90158-0},
journal = {Environ. Res.; (United States)},
number = ,
volume = 18:1,
place = {United States},
year = {1979},
month = {2}
}