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Title: Stimulation of mouse megakaryocyte endomitosis by plasma from thrombocytopenic rats

Abstract

Injection of plasma from thrombocytopenic donor rats resulted in an increase in the endomitotic index of megakaryocytes of recipient mice 32 hr after the initial treatment with plasma. The results suggested a dose-response relationship between the amount of plasma administered and the degree of stimulation of megakaryocytopoiesis. These findings demonstrate that an agent capable of stimulating megakaryocytopoiesis is released in response to thrombocytopenia and that this factor can be successfully transferred between species. They also substantiate the assumption that the increase in peripheral platelet numbers and in platelet labeling after administration of presumptive TSF occurs via stimulation of megakaryocytopoiesis.

Authors:
; ; ;
Publication Date:
Research Org.:
Oak Ridge National Lab., TN
OSTI Identifier:
5370314
DOE Contract Number:  
W-7405-ENG-26
Resource Type:
Journal Article
Journal Name:
Proc. Soc. Exp. Biol. Med.; (United States)
Additional Journal Information:
Journal Volume: 160:2
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; BLOOD FORMATION; STIMULATION; BONE MARROW CELLS; HEMIC DISEASES; BIOLOGICAL EFFECTS; BLOOD PLASMA; BLOOD PLATELETS; CELL NUCLEI; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIPS; DYNAMIC FUNCTION STUDIES; EXPERIMENTAL DATA; ISOLATED VALUES; MICE; MITOTIC INDEX; RATS; RESPONSE MODIFYING FACTORS; SUBCUTANEOUS INJECTION; ANIMAL CELLS; ANIMALS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CELL CONSTITUENTS; CONNECTIVE TISSUE CELLS; DATA; DATA FORMS; DISEASES; INFORMATION; INJECTION; INTAKE; MAMMALS; MATERIALS; NUMERICAL DATA; RODENTS; SOMATIC CELLS; VERTEBRATES; 550900* - Pathology; 551000 - Physiological Systems; 550300 - Cytology

Citation Formats

Odell, T.T., McDonald, T.P., Shelton, C., and Clift, R. Stimulation of mouse megakaryocyte endomitosis by plasma from thrombocytopenic rats. United States: N. p., 1979. Web. doi:10.3181/00379727-160-40431.
Odell, T.T., McDonald, T.P., Shelton, C., & Clift, R. Stimulation of mouse megakaryocyte endomitosis by plasma from thrombocytopenic rats. United States. doi:10.3181/00379727-160-40431.
Odell, T.T., McDonald, T.P., Shelton, C., and Clift, R. Thu . "Stimulation of mouse megakaryocyte endomitosis by plasma from thrombocytopenic rats". United States. doi:10.3181/00379727-160-40431.
@article{osti_5370314,
title = {Stimulation of mouse megakaryocyte endomitosis by plasma from thrombocytopenic rats},
author = {Odell, T.T. and McDonald, T.P. and Shelton, C. and Clift, R.},
abstractNote = {Injection of plasma from thrombocytopenic donor rats resulted in an increase in the endomitotic index of megakaryocytes of recipient mice 32 hr after the initial treatment with plasma. The results suggested a dose-response relationship between the amount of plasma administered and the degree of stimulation of megakaryocytopoiesis. These findings demonstrate that an agent capable of stimulating megakaryocytopoiesis is released in response to thrombocytopenia and that this factor can be successfully transferred between species. They also substantiate the assumption that the increase in peripheral platelet numbers and in platelet labeling after administration of presumptive TSF occurs via stimulation of megakaryocytopoiesis.},
doi = {10.3181/00379727-160-40431},
journal = {Proc. Soc. Exp. Biol. Med.; (United States)},
number = ,
volume = 160:2,
place = {United States},
year = {1979},
month = {2}
}