Research and clinical potential of receptor based radiopharmaceuticals

Journal Article · Sat Jun 01 00:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:5369860

Kilbourn, M R; Zalutsky, M R

Receptors are proteins that have specific binding affinity for substances that produce a physiological event in the body. Receptor-binding radiotracers are being used increasingly to study the function of receptors in health and disease. This review summarizes the proceedings of a symposium on research in the development of receptor-binding radiopharmaceuticals. The key phases in this research include: (1) selection of the receptor system and ligand; (2) synthesis of radiolabeled ligand; (3) validation in animal models; and (4) clinical application. Current research involves a variety of biological systems, such as butyrophenone neuroleptics for dopamine receptors and steroidal estrogens for the estrogen receptor. In the future, it is believed that receptor-binding radiopharmaceuticals will be useful, not only to validate receptor systems in vivo, but also to aid in the diagnosis and therapy of human diseases.

• Research Organization: Washington Univ. School of Medicine, St. Louis, MO
• OSTI ID: 5369860
• Journal Information: J. Nucl. Med.; (United States), Vol. 26:6
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
DOPAMINE
RECEPTORS
ESTROGENS
RADIORECEPTOR ASSAY
DIAGNOSTIC USES
BIOLOGICAL MODELS
IN VIVO
LIGANDS
PROTEINS
RADIOPHARMACEUTICALS
AMINES
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
CARDIOTONICS
CARDIOVASCULAR AGENTS
DRUGS
HORMONES
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
NEUROREGULATORS
ORGANIC COMPOUNDS
PHENOLS
POLYPHENOLS
STEROID HORMONES
SYMPATHOMIMETICS
TRACER TECHNIQUES
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics