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Title: Positron imaging in ischemic stroke disease using compounds labeled with oxygen 15. Initial results of clinicophysiologic correlations

Abstract

Initial results in over 50 patients with stroke suggest that positron images made during continuous inhalation of carbon dioxide labeled with oxygen 15 and molecular oxygen labeled with oxygen 15 provide data on tissue function that may be relevant to acute stroke management. Five cases illustrate the following findings: 15O-activity patterns observed in areas of ischemic injury or infarction are what one would expect if the 15O distributions represented physiologic functions, such as cerebral blood flow and metabolism. Areas of abnormal 15O activity correlate with the clinical or computed tomographic (CT) localization of the deficit. In studies performed acutely, changes in 15O distributions anticipate alterations in CT scans and may be predictive of outcome. Data related to oxygen metabolism correlate better with tissue viability than do those reflecting cerebral blood flow.

Authors:
; ; ; ; ; ; ;
Publication Date:
OSTI Identifier:
5367509
Resource Type:
Journal Article
Journal Name:
Arch. Neurol.; (United States)
Additional Journal Information:
Journal Volume: 38:9
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; BRAIN; SCINTISCANNING; ISCHEMIA; DIAGNOSIS; OXYGEN 15; DIAGNOSTIC USES; VASCULAR DISEASES; BLOOD FLOW; CARBON DIOXIDE; INHALATION; LABELLED COMPOUNDS; METABOLISM; OXYGEN; PATHOLOGY; PATIENTS; PHYSIOLOGY; POSITRON COMPUTED TOMOGRAPHY; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CARBON COMPOUNDS; CARBON OXIDES; CARDIOVASCULAR DISEASES; CENTRAL NERVOUS SYSTEM; CHALCOGENIDES; COMPUTERIZED TOMOGRAPHY; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DISEASES; ELEMENTS; EMISSION COMPUTED TOMOGRAPHY; EVEN-ODD NUCLEI; INTAKE; ISOTOPES; LIGHT NUCLEI; MINUTES LIVING RADIOISOTOPES; NERVOUS SYSTEM; NONMETALS; NUCLEI; ORGANS; OXIDES; OXYGEN COMPOUNDS; OXYGEN ISOTOPES; RADIOISOTOPE SCANNING; RADIOISOTOPES; TOMOGRAPHY; USES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 550901 - Pathology- Tracer Techniques; 551001 - Physiological Systems- Tracer Techniques

Citation Formats

Ackerman, R H, Correia, J A, Alpert, N M, Baron, J C, Gouliamos, A, Grotta, J C, Brownell, G L, and Taveras, J M. Positron imaging in ischemic stroke disease using compounds labeled with oxygen 15. Initial results of clinicophysiologic correlations. United States: N. p., 1981. Web. doi:10.1001/archneur.1981.00510090031002.
Ackerman, R H, Correia, J A, Alpert, N M, Baron, J C, Gouliamos, A, Grotta, J C, Brownell, G L, & Taveras, J M. Positron imaging in ischemic stroke disease using compounds labeled with oxygen 15. Initial results of clinicophysiologic correlations. United States. https://doi.org/10.1001/archneur.1981.00510090031002
Ackerman, R H, Correia, J A, Alpert, N M, Baron, J C, Gouliamos, A, Grotta, J C, Brownell, G L, and Taveras, J M. 1981. "Positron imaging in ischemic stroke disease using compounds labeled with oxygen 15. Initial results of clinicophysiologic correlations". United States. https://doi.org/10.1001/archneur.1981.00510090031002.
@article{osti_5367509,
title = {Positron imaging in ischemic stroke disease using compounds labeled with oxygen 15. Initial results of clinicophysiologic correlations},
author = {Ackerman, R H and Correia, J A and Alpert, N M and Baron, J C and Gouliamos, A and Grotta, J C and Brownell, G L and Taveras, J M},
abstractNote = {Initial results in over 50 patients with stroke suggest that positron images made during continuous inhalation of carbon dioxide labeled with oxygen 15 and molecular oxygen labeled with oxygen 15 provide data on tissue function that may be relevant to acute stroke management. Five cases illustrate the following findings: 15O-activity patterns observed in areas of ischemic injury or infarction are what one would expect if the 15O distributions represented physiologic functions, such as cerebral blood flow and metabolism. Areas of abnormal 15O activity correlate with the clinical or computed tomographic (CT) localization of the deficit. In studies performed acutely, changes in 15O distributions anticipate alterations in CT scans and may be predictive of outcome. Data related to oxygen metabolism correlate better with tissue viability than do those reflecting cerebral blood flow.},
doi = {10.1001/archneur.1981.00510090031002},
url = {https://www.osti.gov/biblio/5367509}, journal = {Arch. Neurol.; (United States)},
number = ,
volume = 38:9,
place = {United States},
year = {Tue Sep 01 00:00:00 EDT 1981},
month = {Tue Sep 01 00:00:00 EDT 1981}
}