Carbogen breathing during radiation therapy. The radiation therapy oncology group study
- Univ. of Rochester Cancer Center, NY
The Radiation Therapy Oncology Group (RTOG) Study, in which 254 patients were analyzed, adjunctive carbogen breathing in irradiation of carcinomas of the oral cavity, oropharynx, nasopharynx, hypopharynx, and larynx failed to bring aboout a gain in survival at any of these sites. In only two of the five regional subgroups did results show any improvement with respect to patients in the Carbogen group as compared to those in the Air group, i.e., the larynx and hypopharynx subgroups. Since both of these subgroups contained relatively small numbers of patients (42 larynx, 39 hypopharynx), it was not possible to declare these improvements as definitely due to carbogen breathing. In the case of the larynx subgroup, improvement might have been due to the slightly unequal distribution with respect to T-stage; in either subgroup, the possibility that apparent improvement was due to nothing more than random variation could not be ruled out. In the subgroups with larger numbers of patients, i.e., the oral cavity and oropharynx groups, there was no demonstrated improvement accompanying carbogen breathing.
- OSTI ID:
- 5366264
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 5:11-12
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOMAS
RADIOTHERAPY
HEAD
X RADIATION
NECK
OXYGEN
RADIOSENSITIVITY EFFECTS
BREATH
DATA
EDEMA
FIBROSIS
FISTULAE
NECROSIS
ORAL CAVITY
PATIENTS
SIDE EFFECTS
TABLES
BODY
BODY AREAS
CRYOGENIC FLUIDS
DATA FORMS
DIGESTIVE SYSTEM
DISEASES
ELECTROMAGNETIC RADIATION
ELEMENTS
FLUIDS
INFORMATION
IONIZING RADIATIONS
MEDICINE
NEOPLASMS
NONMETALS
NUCLEAR MEDICINE
PATHOLOGICAL CHANGES
RADIATIONS
RADIOLOGY
SYMPTOMS
THERAPY
560151* - Radiation Effects on Animals- Man
550603 - Medicine- External Radiation in Therapy- (1980-)