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Title: Metabolism of selenium in skeletal muscle and liver of mice with genetic muscular dystrophy

Abstract

The specific activity of glutathione peroxidase and the concentration of selenium in muscles from mice with genetic muscular dystrophy were both significantly increased over those of control mice. Following pretreatment with sodium selenite (10 ..mu..g/100 g body wt) for 3 days, the specific activity of glutathione peroxidase and the concentration of selenium in muscle from the dystrophic mice were both significantly increased over values in muscle from control mice. When the dystrophic and control mice were fed a diet deficient in selenium, both the activity of glutathione peroxidase and the selenium concentration were significantly decreased in muscle from both groups. However, the magnitude of decrease was significantly greater in the muscle from the control mice than in the muscle from the dystrophic mice. These results suggest that muscle from dystrophic mice has a greater capacity for selenium absorption and retention than does muscle from control mice.

Authors:
; ;
Publication Date:
Research Org.:
Oak Ridge National Lab., TN
OSTI Identifier:
5365817
Resource Type:
Journal Article
Journal Name:
Proc. Soc. Exp. Biol. Med.; (United States)
Additional Journal Information:
Journal Volume: 160:2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; MUSCLES; HEREDITARY DISEASES; PEROXIDASES; ENZYME ACTIVITY; SELENIUM; METABOLISM; ABSORPTION; BIOCHEMICAL REACTION KINETICS; CATALYSIS; COMPARATIVE EVALUATIONS; EXPERIMENTAL DATA; GLUTATHIONE; ISOLATED VALUES; MICE; NUTRITIONAL DEFICIENCY; RESPONSE MODIFYING FACTORS; RETENTION; SELENIUM 75; TISSUE DISTRIBUTION; TRACER TECHNIQUES; ANIMALS; BETA DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; DATA; DATA FORMS; DAYS LIVING RADIOISOTOPES; DISEASES; DISTRIBUTION; ELECTRON CAPTURE RADIOISOTOPES; ELEMENTS; ENZYMES; EVEN-ODD NUCLEI; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; INFORMATION; INTERMEDIATE MASS NUCLEI; ISOTOPE APPLICATIONS; ISOTOPES; KINETICS; MAMMALS; NUCLEI; NUMERICAL DATA; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; OXIDOREDUCTASES; PEPTIDES; POLYPEPTIDES; PORPHYRINS; PROTEINS; RADIOISOTOPES; REACTION KINETICS; RODENTS; SELENIUM ISOTOPES; SEMIMETALS; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987); 551001 - Physiological Systems- Tracer Techniques

Citation Formats

Revis, N.W., Horton, C.Y., and Curtis, S. Metabolism of selenium in skeletal muscle and liver of mice with genetic muscular dystrophy. United States: N. p., 1979. Web. doi:10.3181/00379727-160-40406.
Revis, N.W., Horton, C.Y., & Curtis, S. Metabolism of selenium in skeletal muscle and liver of mice with genetic muscular dystrophy. United States. doi:10.3181/00379727-160-40406.
Revis, N.W., Horton, C.Y., and Curtis, S. Thu . "Metabolism of selenium in skeletal muscle and liver of mice with genetic muscular dystrophy". United States. doi:10.3181/00379727-160-40406.
@article{osti_5365817,
title = {Metabolism of selenium in skeletal muscle and liver of mice with genetic muscular dystrophy},
author = {Revis, N.W. and Horton, C.Y. and Curtis, S.},
abstractNote = {The specific activity of glutathione peroxidase and the concentration of selenium in muscles from mice with genetic muscular dystrophy were both significantly increased over those of control mice. Following pretreatment with sodium selenite (10 ..mu..g/100 g body wt) for 3 days, the specific activity of glutathione peroxidase and the concentration of selenium in muscle from the dystrophic mice were both significantly increased over values in muscle from control mice. When the dystrophic and control mice were fed a diet deficient in selenium, both the activity of glutathione peroxidase and the selenium concentration were significantly decreased in muscle from both groups. However, the magnitude of decrease was significantly greater in the muscle from the control mice than in the muscle from the dystrophic mice. These results suggest that muscle from dystrophic mice has a greater capacity for selenium absorption and retention than does muscle from control mice.},
doi = {10.3181/00379727-160-40406},
journal = {Proc. Soc. Exp. Biol. Med.; (United States)},
number = ,
volume = 160:2,
place = {United States},
year = {1979},
month = {2}
}