CT-SPECT fusion to correlate radiolabeled monoclonal antibody uptake with abdominal CT findings

Journal Article · Fri Sep 01 00:00:00 EDT 1989 · Radiology; (USA)

DOI:https://doi.org/10.1148/radiology.172.3.2788895· OSTI ID:5361181

Kramer, E L; Noz, M E; Sanger, J J; Megibow, A J; Maguire, G Q ^[1]

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1. Memorial Sloan-Kettering Cancer Center, New York, NY (USA)

To enhance the information provided by computed tomography (CT) and single photon emission computed tomography (SPECT) performed with radiolabeled, anti-carcinoembryonic antigen monoclonal antibody (MoAb), the authors performed fusion of these types of images from eight subjects with suspected colorectal adenocarcinoma. Section thickness and pixel size of the two studies were matched, coordinates of corresponding points from each study were identified, and CT sections were translated, rotated, and reprojected to match the corresponding SPECT scans. The CT-SPECT fusion enabled identification of anatomic sites of tumor-specific MoAb accumulation in four cases, showed non-specific MoAb accumulation in two, and helped confirm information only suggested by the two studies separately in one.

• OSTI ID: 5361181
• Journal Information: Radiology; (USA), Vol. 172:3; ISSN 0033-8419
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOMAS
DIAGNOSIS
LARGE INTESTINE
RECTUM
CARCINOEMBRYONIC ANTIGEN
INDIUM ISOTOPES
MONOCLONAL ANTIBODIES
RADIOIMMUNOSCINTIGRAPHY
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
ANTIBODIES
ANTIGENS
BODY
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
EMISSION COMPUTED TOMOGRAPHY
GASTROINTESTINAL TRACT
INTESTINES
ISOTOPE APPLICATIONS
ISOTOPES
NEOPLASMS
ORGANS
RADIOIMMUNODETECTION
RADIOISOTOPE SCANNING
SCINTISCANNING
TOMOGRAPHY
TRACER TECHNIQUES
550601* - Medicine- Unsealed Radionuclides in Diagnostics