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Title: Radiotoxicity of gadolinium-148 and radium-223 in mouse testes: Relative biological effectiveness of alpha-particle emitters in vivo

Abstract

The biological effects of radionuclides that emit {alpha} particles are of considerable interest in view of their potential for therapy and their presence in the environment. The present work is a continuation of our ongoing effort to study the radiotoxicity of {alpha}-particle emitters in vivo using the survival of murine testicular sperm heads as the biological end point. Specifically, the relative biological effectiveness (RBE) of very low-energy {alpha} particles (3.2 MeV) emitted by {sup 148}Gd is investigated and determined to be 7.4 {+-} 2.4 when compared to the effects of acute external 120 kVp X rays. This datum, in conjunction with our earlier results for {sup 210}Po and {sup 212}Pb in equilibrium with its daughters, is used to revise and extend the range of validity of our previous RBE-energy relationship for {alpha} particles emitted by tissue-incorporated radionuclides. The new empirical relationship is given by RBE{sub {alpha}} = 9.14 - 0.510 E{sub {alpha}}, where 3 < E{sub {alpha}} < 9 MeV. The validity of this empirical relationship is tested by determining the RBE of the prolific {alpha}-particle emitter {sup 223}Ra (in equilibrium with its daughters) experimentally in the same biological model and comparing the value obtained experimentally with the predicted value.more » The resulting RBE values are 5.4 {+-} 0.9 and 5.6, respectively. This close agreement strongly supports the adequacy of the empirical RBE-E{sub {alpha}} relationship to predict the biological effects of {alpha}-particle emitters in vivo. 42 refs., 5 figs., 1 tab.« less

Authors:
; ;  [1]
  1. UMDNJ-New Jersey Medical School, Newark, NJ (United States); and others
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
535366
DOE Contract Number:  
AC06-76RL01830
Resource Type:
Journal Article
Journal Name:
Radiation Research
Additional Journal Information:
Journal Volume: 147; Journal Issue: 3; Other Information: PBD: Mar 1997
Country of Publication:
United States
Language:
English
Subject:
56 BIOLOGY AND MEDICINE, APPLIED STUDIES; TESTES; BIOLOGICAL RADIATION EFFECTS; ALPHA PARTICLES; GADOLINIUM 148; RADIUM 223; RBE; RADIOTHERAPY; TOXICITY; MICE

Citation Formats

Howell, R W, Goddu, S M, and Narra, V R. Radiotoxicity of gadolinium-148 and radium-223 in mouse testes: Relative biological effectiveness of alpha-particle emitters in vivo. United States: N. p., 1997. Web. doi:10.2307/3579342.
Howell, R W, Goddu, S M, & Narra, V R. Radiotoxicity of gadolinium-148 and radium-223 in mouse testes: Relative biological effectiveness of alpha-particle emitters in vivo. United States. https://doi.org/10.2307/3579342
Howell, R W, Goddu, S M, and Narra, V R. 1997. "Radiotoxicity of gadolinium-148 and radium-223 in mouse testes: Relative biological effectiveness of alpha-particle emitters in vivo". United States. https://doi.org/10.2307/3579342.
@article{osti_535366,
title = {Radiotoxicity of gadolinium-148 and radium-223 in mouse testes: Relative biological effectiveness of alpha-particle emitters in vivo},
author = {Howell, R W and Goddu, S M and Narra, V R},
abstractNote = {The biological effects of radionuclides that emit {alpha} particles are of considerable interest in view of their potential for therapy and their presence in the environment. The present work is a continuation of our ongoing effort to study the radiotoxicity of {alpha}-particle emitters in vivo using the survival of murine testicular sperm heads as the biological end point. Specifically, the relative biological effectiveness (RBE) of very low-energy {alpha} particles (3.2 MeV) emitted by {sup 148}Gd is investigated and determined to be 7.4 {+-} 2.4 when compared to the effects of acute external 120 kVp X rays. This datum, in conjunction with our earlier results for {sup 210}Po and {sup 212}Pb in equilibrium with its daughters, is used to revise and extend the range of validity of our previous RBE-energy relationship for {alpha} particles emitted by tissue-incorporated radionuclides. The new empirical relationship is given by RBE{sub {alpha}} = 9.14 - 0.510 E{sub {alpha}}, where 3 < E{sub {alpha}} < 9 MeV. The validity of this empirical relationship is tested by determining the RBE of the prolific {alpha}-particle emitter {sup 223}Ra (in equilibrium with its daughters) experimentally in the same biological model and comparing the value obtained experimentally with the predicted value. The resulting RBE values are 5.4 {+-} 0.9 and 5.6, respectively. This close agreement strongly supports the adequacy of the empirical RBE-E{sub {alpha}} relationship to predict the biological effects of {alpha}-particle emitters in vivo. 42 refs., 5 figs., 1 tab.},
doi = {10.2307/3579342},
url = {https://www.osti.gov/biblio/535366}, journal = {Radiation Research},
number = 3,
volume = 147,
place = {United States},
year = {Sat Mar 01 00:00:00 EST 1997},
month = {Sat Mar 01 00:00:00 EST 1997}
}