Phosphorylation as a method of regulating the activity of yeast inorganic pyrophosphatase. I. Activation of inorganic pyrophosphatase under the action of ATP

Journal Article · Tue Apr 01 00:00:00 EST 1986 · Sov. J. Bioorg. Chem. (Engl. Transl.); (United States)

OSTI ID:5349280

Vener, A V; Nazarova, T I; Avaeva, S M

ATP activates in a noncompetitive manner the hydrolysis of magnesium pyrophosphate catalyzed by baker's yeast inorganic pyrophosphatase. On the other hand, ATP causes a fall in the amount of pyrophosphate bound with enzyme that is formed by synthesis from phosphate, which confirms the fact of an increase in the catalytic rate constant of the enzymatic hydrolysis of pyrophosphate. The reason for the activation of the inorganic pyrophosphatase is the phosphorylation of its regulatory center under the action of ATP with the inclusion of the ..gamma..-phosphate group of the ATP in the protein.

• Research Organization: M. V. Lomonosov Moscow State Univ. (USSR)
• OSTI ID: 5349280
• Journal Information: Sov. J. Bioorg. Chem. (Engl. Transl.); (United States), Vol. 11:6; Other Information: Translated from Bioorganicheskaya Khim; 11: No. 6, 784-790(Jun 1985)
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ATP
ACTIVATION ENERGY
PHOSPHATASES
ENZYME ACTIVITY
METABOLIC ACTIVATION
PHOSPHORYLATION
PYROPHOSPHATES
ENZYMATIC HYDROLYSIS
RADIOENZYMATIC ASSAY
BIOCHEMICAL REACTION KINETICS
CARBON 14 COMPOUNDS
CATALYTIC EFFECTS
LABELLED COMPOUNDS
LABELLING
MAGNESIUM COMPOUNDS
PHOSPHORUS 32
YEASTS
ZINC COMPOUNDS
ALKALINE EARTH METAL COMPOUNDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHEMICAL REACTIONS
DAYS LIVING RADIOISOTOPES
DECOMPOSITION
ENERGY
ENZYMES
ESTERASES
FUNGI
HYDROLASES
HYDROLYSIS
ISOTOPES
KINETICS
LIGHT NUCLEI
LYSIS
MICROORGANISMS
NUCLEI
NUCLEOTIDES
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
OXYGEN COMPOUNDS
PHOSPHORUS COMPOUNDS
PHOSPHORUS ISOTOPES
PLANTS
RADIOISOTOPES
REACTION KINETICS
SOLVOLYSIS
550201* - Biochemistry- Tracer Techniques