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Title: Ultrastructural and x-ray microanalytical observations of minocycline-related hyperpigmentation of the skin

Abstract

In order to elucidate the nature and distribution of the pigment responsible for the circumscribed blue-black cutaneous hyperpigmentation occurring after administration of minocycline hydrochloride, transmission electron microscopy and energy-dispersive electron x-ray microanalysis were performed on lesional skin. Ultrastructural observations demonstrated electron-dense iron-containing particles either incorporated into a variety of siderosomes, within dermal histiocytes, free within the cytoplasm, or, rarely, scattered among dermal collagen fibers. Electron x-ray microanalysis confirmed iron content present within these particles. Although siderosomal inclusions contained occasional melanosome complexes, the degree of deposition of electron-dense iron-containing particles in dermal histiocytes seemed to be primarily responsible for the blue-black discoloration of the skin. The present study is an investigation of the structure and composition of the pigment responsible for minocycline-related cutaneous hyperpigmentation.

Authors:
; ; ; ;
Publication Date:
OSTI Identifier:
5348616
Resource Type:
Journal Article
Journal Name:
J. Invest. Dermatol.; (United States)
Additional Journal Information:
Journal Volume: 77:3
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; PIGMENTS; STRUCTURAL CHEMICAL ANALYSIS; SKIN; SENSITIVITY; TETRACYCLINES; BIOLOGICAL EFFECTS; COLLAGEN; CYTOPLASM; ELECTRON MICROPROBE ANALYSIS; IRON; TISSUE DISTRIBUTION; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURAL CHANGES; X-RAY EMISSION ANALYSIS; ANTI-INFECTIVE AGENTS; ANTIBIOTICS; BODY; CELL CONSTITUENTS; CHEMICAL ANALYSIS; DISTRIBUTION; DRUGS; ELECTRON MICROSCOPY; ELEMENTS; METALS; MICROANALYSIS; MICROSCOPY; MORPHOLOGICAL CHANGES; NONDESTRUCTIVE ANALYSIS; ORGANIC COMPOUNDS; ORGANS; PROTEINS; SCLEROPROTEINS; TRANSITION ELEMENTS; 550200* - Biochemistry; 560306 - Chemicals Metabolism & Toxicology- Man- (-1987); 550300 - Cytology

Citation Formats

Sato, S, Murphy, G F, Bernhard, J D, Mihm, Jr, M C, and Fitzpatrick, T B. Ultrastructural and x-ray microanalytical observations of minocycline-related hyperpigmentation of the skin. United States: N. p., 1981. Web. doi:10.1111/1523-1747.ep12482449.
Sato, S, Murphy, G F, Bernhard, J D, Mihm, Jr, M C, & Fitzpatrick, T B. Ultrastructural and x-ray microanalytical observations of minocycline-related hyperpigmentation of the skin. United States. https://doi.org/10.1111/1523-1747.ep12482449
Sato, S, Murphy, G F, Bernhard, J D, Mihm, Jr, M C, and Fitzpatrick, T B. Tue . "Ultrastructural and x-ray microanalytical observations of minocycline-related hyperpigmentation of the skin". United States. https://doi.org/10.1111/1523-1747.ep12482449.
@article{osti_5348616,
title = {Ultrastructural and x-ray microanalytical observations of minocycline-related hyperpigmentation of the skin},
author = {Sato, S and Murphy, G F and Bernhard, J D and Mihm, Jr, M C and Fitzpatrick, T B},
abstractNote = {In order to elucidate the nature and distribution of the pigment responsible for the circumscribed blue-black cutaneous hyperpigmentation occurring after administration of minocycline hydrochloride, transmission electron microscopy and energy-dispersive electron x-ray microanalysis were performed on lesional skin. Ultrastructural observations demonstrated electron-dense iron-containing particles either incorporated into a variety of siderosomes, within dermal histiocytes, free within the cytoplasm, or, rarely, scattered among dermal collagen fibers. Electron x-ray microanalysis confirmed iron content present within these particles. Although siderosomal inclusions contained occasional melanosome complexes, the degree of deposition of electron-dense iron-containing particles in dermal histiocytes seemed to be primarily responsible for the blue-black discoloration of the skin. The present study is an investigation of the structure and composition of the pigment responsible for minocycline-related cutaneous hyperpigmentation.},
doi = {10.1111/1523-1747.ep12482449},
url = {https://www.osti.gov/biblio/5348616}, journal = {J. Invest. Dermatol.; (United States)},
number = ,
volume = 77:3,
place = {United States},
year = {1981},
month = {9}
}