Health effects of haloalkyl phoshpate flame retardants and potential metabolic products
The purpose of this study was to produce a state-of-the-art review and assessment of the health effects associated with tris(1,3-dichloro-2-propyl) phosphate (TDCP) and related compounds which find widespread use as flame retardants. It was intended to support an ongoing evaluation of TDCP within the Office of Toxic Substances. TDCP was demonstrated to be a potent oncogen in a 2-year chronic study in rats. It is probable that the oncogenicity of TDCP is due, in part or in total, to the production of reactive metabolic intermediates which are well-known mutagens. As an example, 1,3-dichloro-2-propanone is a bifunctional alkylating agent with intercalating properties. Its carbonyl functional group is potentially reactive as well. Therefore, it is not surprising that it has been shown to be a very potent in vitro mutagen. This examination of the metabolic pathways of TDCP with emphasis on oxidative processes common to organophosphate compounds, and documentation of the health effects of halogenated carbonyl-containing compounds, which may be generated metabolically, will assist in the assessment of health hazards made in the absence of extensive further testing.
- Research Organization:
- Oak Ridge National Lab., TN (USA)
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 5332712
- Report Number(s):
- DOE/NBM-4006848; ON: DE84006848
- Country of Publication:
- United States
- Language:
- English
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ORGANIC CHLORINE COMPOUNDS
CARCINOGENESIS
GASTROINTESTINAL TRACT
METABOLISM
MUTAGEN SCREENING
SKIN ABSORPTION
TERATOGENESIS
TISSUE DISTRIBUTION
ORGANIC PHOSPHORUS COMPOUNDS
ALCOHOLS
ALKYLATING AGENTS
EPOXIDES
FIRE RESISTANCE
SALMONELLA
TESTES
ABSORPTION
BACTERIA
BODY
DIGESTIVE SYSTEM
DISTRIBUTION
GONADS
HYDROXY COMPOUNDS
MALE GENITALS
MICROORGANISMS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PATHOGENESIS
SCREENING
UPTAKE
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
560302 - Chemicals Metabolism & Toxicology- Microorganisms- (-1987)