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Title: In vivo-detection, localization and measurement of radionuclides in man: a detection system for the localization amd measurement of small amounts of photon emitters. Progress report, March 1, 1981-October 31, 1981

Abstract

The design, construction, and testing of a photon detection system which will yield, simultaneously, information proportional to both the magnitude and location of sources of radioactivity are under investigation. The operating principle of the detector system, active collimation, allows spatial resolution by utilizing the crystal elements themselves as the collimating device; hence a greater counting efficiency is attainable. Two approaches have been tested thus far: in the first, the differences in characteristics of various crystals are utilized as the means of separating events occurring in each of five crystals viewed by a single phototube; in the second, smaller, single crystal/phototube elements are used in the array. Mathematical processing of the counts from the individual crystal elements is then employed in conjunction with their geometric relationship to develop both positional data and to quantify the amount of radioactivity. By utilizing crystal elements in an active collimation configuration and incorporating them in an array which permits these crystals to be alternately advanced and retracted in a programmed, ordered manner, a high degree of spatial resolution is achievable without compromising system sensitivity. The experiments include development of the optimal crystal configuration and the evolving of data processing techniques to translate detector response intomore » precise source position information for localization or imaging purposes. Such a system could add another dimension in studies involving uptake, distribution, and retention of radionuclide labeled compounds because of its ability to actively track, in vivo, the distribution of these compounds. In addition, it should be possible to study, dynamically, the motion of organs, such as the heart or lungs, through which these compounds move. (ERB)« less

Authors:
Publication Date:
Research Org.:
New York Univ., NY (USA). Medical Center
OSTI Identifier:
5309681
Report Number(s):
DOE/EV/04957-T1; COO-4957-3
ON: DE82005466
DOE Contract Number:  
AS02-78EV04957
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; 62 RADIOLOGY AND NUCLEAR MEDICINE; NUCLEAR MEDICINE; GAMMA DETECTION; SOLID SCINTILLATION DETECTORS; DESIGN; FABRICATION; PERFORMANCE TESTING; COLLIMATORS; CRYSTALS; DATA PROCESSING; DYNAMIC FUNCTION STUDIES; EXPERIMENTAL DATA; IN VIVO; RADIONUCLIDE KINETICS; SENSITIVITY; SPATIAL RESOLUTION; DATA; DETECTION; INFORMATION; MEASURING INSTRUMENTS; MEDICINE; NUMERICAL DATA; PROCESSING; RADIATION DETECTION; RADIATION DETECTORS; RESOLUTION; SCINTILLATION COUNTERS; TESTING; 440101* - Radiation Instrumentation- General Detectors or Monitors & Radiometric Instruments; 550601 - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Laurer, G. R. In vivo-detection, localization and measurement of radionuclides in man: a detection system for the localization amd measurement of small amounts of photon emitters. Progress report, March 1, 1981-October 31, 1981. United States: N. p., 1981. Web. doi:10.2172/5309681.
Laurer, G. R. In vivo-detection, localization and measurement of radionuclides in man: a detection system for the localization amd measurement of small amounts of photon emitters. Progress report, March 1, 1981-October 31, 1981. United States. https://doi.org/10.2172/5309681
Laurer, G. R. 1981. "In vivo-detection, localization and measurement of radionuclides in man: a detection system for the localization amd measurement of small amounts of photon emitters. Progress report, March 1, 1981-October 31, 1981". United States. https://doi.org/10.2172/5309681. https://www.osti.gov/servlets/purl/5309681.
@article{osti_5309681,
title = {In vivo-detection, localization and measurement of radionuclides in man: a detection system for the localization amd measurement of small amounts of photon emitters. Progress report, March 1, 1981-October 31, 1981},
author = {Laurer, G. R.},
abstractNote = {The design, construction, and testing of a photon detection system which will yield, simultaneously, information proportional to both the magnitude and location of sources of radioactivity are under investigation. The operating principle of the detector system, active collimation, allows spatial resolution by utilizing the crystal elements themselves as the collimating device; hence a greater counting efficiency is attainable. Two approaches have been tested thus far: in the first, the differences in characteristics of various crystals are utilized as the means of separating events occurring in each of five crystals viewed by a single phototube; in the second, smaller, single crystal/phototube elements are used in the array. Mathematical processing of the counts from the individual crystal elements is then employed in conjunction with their geometric relationship to develop both positional data and to quantify the amount of radioactivity. By utilizing crystal elements in an active collimation configuration and incorporating them in an array which permits these crystals to be alternately advanced and retracted in a programmed, ordered manner, a high degree of spatial resolution is achievable without compromising system sensitivity. The experiments include development of the optimal crystal configuration and the evolving of data processing techniques to translate detector response into precise source position information for localization or imaging purposes. Such a system could add another dimension in studies involving uptake, distribution, and retention of radionuclide labeled compounds because of its ability to actively track, in vivo, the distribution of these compounds. In addition, it should be possible to study, dynamically, the motion of organs, such as the heart or lungs, through which these compounds move. (ERB)},
doi = {10.2172/5309681},
url = {https://www.osti.gov/biblio/5309681}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Sun Nov 01 00:00:00 EST 1981},
month = {Sun Nov 01 00:00:00 EST 1981}
}